Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple functions including learning and memory processes. Alterations of this system con...

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Bibliographic Details
Main Authors: Alba Navarro-Romero, Anna Vázquez-Oliver, Maria Gomis-González, Carlos Garzón-Montesinos, Rafael Falcón-Moya, Antoni Pastor, Elena Martín-García, Nieves Pizarro, Arnau Busquets-Garcia, Jean-Michel Revest, Pier-Vincenzo Piazza, Fátima Bosch, Mara Dierssen, Rafael de la Torre, Antonio Rodríguez-Moreno, Rafael Maldonado, Andrés Ozaita
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Intellectual disability
Cognitive deficits
Cannabinoid receptor type-1
Endocannabinoid system
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118306855

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http://www.sciencedirect.com/science/article/pii/S0969996118306855

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