Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity wi...

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Main Authors: David Herrero-Martin, Argyro Fourtouna, Stephan Niedan, Lucia T. Riedmann, Raphaela Schwentner, Dave N. T. Aryee
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2011/352580
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spelling doaj-559cd7bed7fd43b9a12f5b1c358060262020-11-25T00:36:23ZengHindawi LimitedSarcoma1357-714X1369-16432011-01-01201110.1155/2011/352580352580Factors Affecting EWS-FLI1 Activity in Ewing's SarcomaDavid Herrero-Martin0Argyro Fourtouna1Stephan Niedan2Lucia T. Riedmann3Raphaela Schwentner4Dave N. T. Aryee5Children's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, AustriaChildren's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, AustriaChildren's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, AustriaChildren's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, AustriaChildren's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, AustriaChildren's Cancer Research Institute, St Anna Kinderkrebsforschung, 1090 Vienna, AustriaEwing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.http://dx.doi.org/10.1155/2011/352580
collection DOAJ
language English
format Article
sources DOAJ
author David Herrero-Martin
Argyro Fourtouna
Stephan Niedan
Lucia T. Riedmann
Raphaela Schwentner
Dave N. T. Aryee
spellingShingle David Herrero-Martin
Argyro Fourtouna
Stephan Niedan
Lucia T. Riedmann
Raphaela Schwentner
Dave N. T. Aryee
Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
Sarcoma
author_facet David Herrero-Martin
Argyro Fourtouna
Stephan Niedan
Lucia T. Riedmann
Raphaela Schwentner
Dave N. T. Aryee
author_sort David Herrero-Martin
title Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
title_short Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
title_full Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
title_fullStr Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
title_full_unstemmed Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
title_sort factors affecting ews-fli1 activity in ewing's sarcoma
publisher Hindawi Limited
series Sarcoma
issn 1357-714X
1369-1643
publishDate 2011-01-01
description Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.
url http://dx.doi.org/10.1155/2011/352580
work_keys_str_mv AT davidherreromartin factorsaffectingewsfli1activityinewingssarcoma
AT argyrofourtouna factorsaffectingewsfli1activityinewingssarcoma
AT stephanniedan factorsaffectingewsfli1activityinewingssarcoma
AT luciatriedmann factorsaffectingewsfli1activityinewingssarcoma
AT raphaelaschwentner factorsaffectingewsfli1activityinewingssarcoma
AT daventaryee factorsaffectingewsfli1activityinewingssarcoma
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