Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells

Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells

Fruit extracts of Basella rubra, which are rich in bioactive phenolics, flavonoids and betalains were investigated for their antioxidant and anticancer activities against human cervical carcinoma (SiHa) cells. The fruits contained total betalain contents of 0.34 g/100 g fresh weight and 1.9 g/100 g...

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Main Authors: Sandopu Sravan Kumar, Prabhakaran Manoj, Parvatam Giridhar, Richa Shrivastava, Mausumi Bharadwaj
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Functional Foods
Subjects:
B. rubra L.
Betalains
Phenolics
Antioxidant
Anticancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615001693
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spelling doaj-559f05d28ffc49dc9e4813a5cd581c712021-04-29T04:44:16ZengElsevierJournal of Functional Foods1756-46462015-05-0115509515Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cellsSandopu Sravan Kumar0Prabhakaran Manoj1Parvatam Giridhar2Richa Shrivastava3Mausumi Bharadwaj4Plant Cell Biotechnology Department, CSIR-Central Food Technological Research Institute, Mysore 570 020, IndiaPlant Cell Biotechnology Department, CSIR-Central Food Technological Research Institute, Mysore 570 020, IndiaPlant Cell Biotechnology Department, CSIR-Central Food Technological Research Institute, Mysore 570 020, India; Corresponding author. Central Food Technological Research Institute, Plant Cell Biotechnology Department, Mysore 570020, India. Tel.: +918212516501; fax: +918212517233.Division of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology, Indian Council of Medical Research, Department of Health Research, Noida 201301, Uttar Pradesh, IndiaDivision of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology, Indian Council of Medical Research, Department of Health Research, Noida 201301, Uttar Pradesh, IndiaFruit extracts of Basella rubra, which are rich in bioactive phenolics, flavonoids and betalains were investigated for their antioxidant and anticancer activities against human cervical carcinoma (SiHa) cells. The fruits contained total betalain contents of 0.34 g/100 g fresh weight and 1.9 g/100 g dry weight. Betanin, isobetanin and gomphrenin I were the major pigments identified. Phenolic compounds, such as generic acid, sinapic acid, ferulic acid, coumaric acid and chlorogenic acid, and flavonoids, such as myricetin, quercetin, luteolin, apigenin and kaempferol, were identified. Both water and aqueous methanol extracts of fruits showed significant free radical scavenging potential and ferric reducing antioxidant power. Fruit extracts at 50 mg/mL showed strong (81%) cytotoxic activity against human cervical carcinoma cells. Thus, fruit extracts have potential application for cancer treatments and as nutraceutical or dietary supplements.http://www.sciencedirect.com/science/article/pii/S1756464615001693B. rubra L.BetalainsPhenolicsAntioxidantAnticancer
collection DOAJ
language English
format Article
sources DOAJ
author Sandopu Sravan Kumar
Prabhakaran Manoj
Parvatam Giridhar
Richa Shrivastava
Mausumi Bharadwaj
spellingShingle Sandopu Sravan Kumar
Prabhakaran Manoj
Parvatam Giridhar
Richa Shrivastava
Mausumi Bharadwaj
Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
Journal of Functional Foods
B. rubra L.
Betalains
Phenolics
Antioxidant
Anticancer
author_facet Sandopu Sravan Kumar
Prabhakaran Manoj
Parvatam Giridhar
Richa Shrivastava
Mausumi Bharadwaj
author_sort Sandopu Sravan Kumar
title Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
title_short Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
title_full Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
title_fullStr Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
title_full_unstemmed Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
title_sort fruit extracts of basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2015-05-01
description Fruit extracts of Basella rubra, which are rich in bioactive phenolics, flavonoids and betalains were investigated for their antioxidant and anticancer activities against human cervical carcinoma (SiHa) cells. The fruits contained total betalain contents of 0.34 g/100 g fresh weight and 1.9 g/100 g dry weight. Betanin, isobetanin and gomphrenin I were the major pigments identified. Phenolic compounds, such as generic acid, sinapic acid, ferulic acid, coumaric acid and chlorogenic acid, and flavonoids, such as myricetin, quercetin, luteolin, apigenin and kaempferol, were identified. Both water and aqueous methanol extracts of fruits showed significant free radical scavenging potential and ferric reducing antioxidant power. Fruit extracts at 50 mg/mL showed strong (81%) cytotoxic activity against human cervical carcinoma cells. Thus, fruit extracts have potential application for cancer treatments and as nutraceutical or dietary supplements.
topic B. rubra L.
Betalains
Phenolics
Antioxidant
Anticancer
url http://www.sciencedirect.com/science/article/pii/S1756464615001693
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AT prabhakaranmanoj fruitextractsofbasellarubrathatarerichinbioactivesandbetalainsexhibitantioxidantactivityandcytotoxicityagainsthumancervicalcarcinomacells
AT parvatamgiridhar fruitextractsofbasellarubrathatarerichinbioactivesandbetalainsexhibitantioxidantactivityandcytotoxicityagainsthumancervicalcarcinomacells
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