Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in humans are linked to functional modifications in th...
Main Authors: | Laura L. Perissinotti, Pablo M. De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C. Lee, Colleen E. Clancy, Henry J. Duff, Sergei Y. Noskov |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-04-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2018.00207/full |
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