GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin
Weight gain and obesity are global health concerns contributing to morbidity with increased risks of cardiovascular disease, diabetes, liver steatohepatitis and cancer. Pharmacological therapies or bariatric surgery are often required for those who fail to adhere to diet and lifestyle modifications....
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2020-11-01
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doaj-55a79b60f93e43bdaec657e1a7e079b92020-11-25T04:11:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-11-011110.3389/fendo.2020.581839581839GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With MetforminJing Ouyang0Jing Ouyang1Jing Ouyang2Stéphane Isnard3Stéphane Isnard4Stéphane Isnard5John Lin6John Lin7Brandon Fombuena8Brandon Fombuena9Brandon Fombuena10Xiaorong Peng11Xiaorong Peng12Xiaorong Peng13Yaokai Chen14Jean-Pierre Routy15Jean-Pierre Routy16Jean-Pierre Routy17Chongqing Public Health Medical Center, Chongqing, ChinaInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, CanadaChronic Viral Illness Service, McGill University Health Centre, Montréal, QC, CanadaInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, CanadaChronic Viral Illness Service, McGill University Health Centre, Montréal, QC, CanadaCIHR Canadian HIV Trials Network, Vancouver, BC, CanadaInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, CanadaChronic Viral Illness Service, McGill University Health Centre, Montréal, QC, CanadaInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, CanadaChronic Viral Illness Service, McGill University Health Centre, Montréal, QC, CanadaDepartment of Microbiology and Immunology, McGill University, Montréal, QC, CanadaInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, CanadaChronic Viral Illness Service, McGill University Health Centre, Montréal, QC, CanadaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaChongqing Public Health Medical Center, Chongqing, ChinaInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health Centre, Montréal, QC, CanadaChronic Viral Illness Service, McGill University Health Centre, Montréal, QC, CanadaDivision of Hematology, McGill University Health Centre, Montréal, QC, CanadaWeight gain and obesity are global health concerns contributing to morbidity with increased risks of cardiovascular disease, diabetes, liver steatohepatitis and cancer. Pharmacological therapies or bariatric surgery are often required for those who fail to adhere to diet and lifestyle modifications. Metformin, a widely used antidiabetic agent, seems to have a health benefit beyond its anti-hyperglycemic properties, with few side effects. Emerging evidence shows weight loss to be associated with metformin in both diabetic and non-diabetic individuals. Recently, the growth differentiation factor 15 (GDF-15), a member of the transforming growth factor beta superfamily, has been identified as a key mediator of metformin-induced weight loss. Metformin increases the secretion of GDF-15, which binds exclusively to glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL). This gut-brain cytokine works as a prominent player in reducing food intake and body weight in health and disease, like anorexia nervosa and cancer. Herein, we critically review advances in the understanding of the weight-reducing effects of metformin via the GDF-15 pathway.https://www.frontiersin.org/articles/10.3389/fendo.2020.581839/fullmetforminbody weightobesityGDF-15GFRALdiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Ouyang Jing Ouyang Jing Ouyang Stéphane Isnard Stéphane Isnard Stéphane Isnard John Lin John Lin Brandon Fombuena Brandon Fombuena Brandon Fombuena Xiaorong Peng Xiaorong Peng Xiaorong Peng Yaokai Chen Jean-Pierre Routy Jean-Pierre Routy Jean-Pierre Routy |
spellingShingle |
Jing Ouyang Jing Ouyang Jing Ouyang Stéphane Isnard Stéphane Isnard Stéphane Isnard John Lin John Lin Brandon Fombuena Brandon Fombuena Brandon Fombuena Xiaorong Peng Xiaorong Peng Xiaorong Peng Yaokai Chen Jean-Pierre Routy Jean-Pierre Routy Jean-Pierre Routy GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin Frontiers in Endocrinology metformin body weight obesity GDF-15 GFRAL diabetes |
author_facet |
Jing Ouyang Jing Ouyang Jing Ouyang Stéphane Isnard Stéphane Isnard Stéphane Isnard John Lin John Lin Brandon Fombuena Brandon Fombuena Brandon Fombuena Xiaorong Peng Xiaorong Peng Xiaorong Peng Yaokai Chen Jean-Pierre Routy Jean-Pierre Routy Jean-Pierre Routy |
author_sort |
Jing Ouyang |
title |
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin |
title_short |
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin |
title_full |
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin |
title_fullStr |
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin |
title_full_unstemmed |
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin |
title_sort |
gdf-15 as a weight watcher for diabetic and non-diabetic people treated with metformin |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-11-01 |
description |
Weight gain and obesity are global health concerns contributing to morbidity with increased risks of cardiovascular disease, diabetes, liver steatohepatitis and cancer. Pharmacological therapies or bariatric surgery are often required for those who fail to adhere to diet and lifestyle modifications. Metformin, a widely used antidiabetic agent, seems to have a health benefit beyond its anti-hyperglycemic properties, with few side effects. Emerging evidence shows weight loss to be associated with metformin in both diabetic and non-diabetic individuals. Recently, the growth differentiation factor 15 (GDF-15), a member of the transforming growth factor beta superfamily, has been identified as a key mediator of metformin-induced weight loss. Metformin increases the secretion of GDF-15, which binds exclusively to glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL). This gut-brain cytokine works as a prominent player in reducing food intake and body weight in health and disease, like anorexia nervosa and cancer. Herein, we critically review advances in the understanding of the weight-reducing effects of metformin via the GDF-15 pathway. |
topic |
metformin body weight obesity GDF-15 GFRAL diabetes |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2020.581839/full |
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