Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children
Background/Purpose: Rotavirus remains a leading cause of pediatric gastroenteritis-related hospitalization. Surveillance studies have revealed that several major rotaviral genotypes are responsible for most cases of rotavirus gastroenteritis (RVGE). This study aimed to understand the characteristics...
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doaj-55b1f51300c34526bc9d0080fedec0cb2020-11-25T03:18:22ZengElsevierJournal of the Formosan Medical Association0929-66462020-07-01119711581166Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese childrenYen-Hsin Kung0Hsin Chi1Ching-Chuan Liu2Yhu-Chering Huang3Yi-Chuan Huang4Fang-Tzy Wu5Li-Min Huang6Department of Pediatrics, Mackay Memorial Hospital and Mackay Children's Hospital, Taipei, TaiwanDepartment of Pediatrics, Mackay Memorial Hospital and Mackay Children's Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Corresponding author. Department of Pediatrics, Mackay Children's Hospital, Mackay Memorial Hospital, Number 92, Sec. 2, Zhongshan North Road, Taipei, Taiwan. Fax: +886 2 2543364.Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Health, Research and Diagnostic Center, Centers for Disease Control, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital, Number 8, Chung-Shan-South Road, Taipei, Taiwan. Fax: +886 2 23147450.Background/Purpose: Rotavirus remains a leading cause of pediatric gastroenteritis-related hospitalization. Surveillance studies have revealed that several major rotaviral genotypes are responsible for most cases of rotavirus gastroenteritis (RVGE). This study aimed to understand the characteristics of acute gastroenteritis (AGE) caused by rotavirus in young children in Taiwan. Methods: Ten hospitals in Taiwan were subjected to prospective hospital-based AGE surveillance during 2014–2017, and children younger than 5 years old who were hospitalized due to AGE were enrolled in the study. Medical and demographic variables were recorded and analyzed, and stool specimens were collected for rotavirus identification and genotyping via real-time RT-PCR. Non-rotavirus AGE age-matched controls were enrolled. Results: Surveillance identified 4747 young children hospitalized with AGE during this study period. The median age of these patients was 2.0 years. Rotavirus was detected in stool samples from 518 patients (10.9%). The prevalent months of RVGE in 2014, 2015, and 2017, wherein the rotavirus positivity rates exceeded 30%. The most common serotypes were G3P[8] (303/518, 58.9%) and G1P[8] (86/518, 16.6%). The percentage of G3P[8] increased from 4.9% in 2014 to 74.3% in 2016 (P < 0.0001), whereas the percentage of G1P[8] decreased from 61.0% in 2014 to 22.5% in 2015 (P < 0.0001). Compared with G3P[8], G1P[8] was associated with a significantly higher C-reactive protein level (P < 0.05). Conclusion: Rotavirus remains a notable pathogenic etiology of childhood AGE and the G3P[8] serotype was dominant in Taiwan. This study highlighted the importance of rotavirus surveillance to ensure protective effectiveness against the circulating strains.http://www.sciencedirect.com/science/article/pii/S092966462030111XChildrenGastroenteritisGenotypeRotavirusVaccine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yen-Hsin Kung Hsin Chi Ching-Chuan Liu Yhu-Chering Huang Yi-Chuan Huang Fang-Tzy Wu Li-Min Huang |
spellingShingle |
Yen-Hsin Kung Hsin Chi Ching-Chuan Liu Yhu-Chering Huang Yi-Chuan Huang Fang-Tzy Wu Li-Min Huang Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children Journal of the Formosan Medical Association Children Gastroenteritis Genotype Rotavirus Vaccine |
author_facet |
Yen-Hsin Kung Hsin Chi Ching-Chuan Liu Yhu-Chering Huang Yi-Chuan Huang Fang-Tzy Wu Li-Min Huang |
author_sort |
Yen-Hsin Kung |
title |
Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children |
title_short |
Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children |
title_full |
Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children |
title_fullStr |
Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children |
title_full_unstemmed |
Hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young Taiwanese children |
title_sort |
hospital-based surveillance of severe rotavirus gastroenteritis and rotavirus strains in young taiwanese children |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2020-07-01 |
description |
Background/Purpose: Rotavirus remains a leading cause of pediatric gastroenteritis-related hospitalization. Surveillance studies have revealed that several major rotaviral genotypes are responsible for most cases of rotavirus gastroenteritis (RVGE). This study aimed to understand the characteristics of acute gastroenteritis (AGE) caused by rotavirus in young children in Taiwan. Methods: Ten hospitals in Taiwan were subjected to prospective hospital-based AGE surveillance during 2014–2017, and children younger than 5 years old who were hospitalized due to AGE were enrolled in the study. Medical and demographic variables were recorded and analyzed, and stool specimens were collected for rotavirus identification and genotyping via real-time RT-PCR. Non-rotavirus AGE age-matched controls were enrolled. Results: Surveillance identified 4747 young children hospitalized with AGE during this study period. The median age of these patients was 2.0 years. Rotavirus was detected in stool samples from 518 patients (10.9%). The prevalent months of RVGE in 2014, 2015, and 2017, wherein the rotavirus positivity rates exceeded 30%. The most common serotypes were G3P[8] (303/518, 58.9%) and G1P[8] (86/518, 16.6%). The percentage of G3P[8] increased from 4.9% in 2014 to 74.3% in 2016 (P < 0.0001), whereas the percentage of G1P[8] decreased from 61.0% in 2014 to 22.5% in 2015 (P < 0.0001). Compared with G3P[8], G1P[8] was associated with a significantly higher C-reactive protein level (P < 0.05). Conclusion: Rotavirus remains a notable pathogenic etiology of childhood AGE and the G3P[8] serotype was dominant in Taiwan. This study highlighted the importance of rotavirus surveillance to ensure protective effectiveness against the circulating strains. |
topic |
Children Gastroenteritis Genotype Rotavirus Vaccine |
url |
http://www.sciencedirect.com/science/article/pii/S092966462030111X |
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