Estrogen induces global reorganization of chromatin structure in human breast cancer cells.
In the cell nucleus, each chromosome is confined to a chromosome territory. This spatial organization of chromosomes plays a crucial role in gene regulation and genome stability. An additional level of organization has been discovered at the chromosome scale: the spatial segregation into open and cl...
Main Authors: | Raphaël Mourad, Pei-Yin Hsu, Liran Juan, Changyu Shen, Prasad Koneru, Hai Lin, Yunlong Liu, Kenneth Nephew, Tim H Huang, Lang Li |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0113354 |
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