Recent Progress of Basic Studies of Natural Products and Their Dental Application
The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous ce...
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doaj-55b3cb19f96f4fddbbe52888e9f3343c2020-11-25T02:00:25ZengMDPI AGMedicines2305-63202018-12-0161410.3390/medicines6010004medicines6010004Recent Progress of Basic Studies of Natural Products and Their Dental ApplicationHiroshi Sakagami0Taihei Watanabe1Tomonori Hoshino2Naoto Suda3Kazumasa Mori4Toshikazu Yasui5Naoki Yamauchi6Harutsugu Kashiwagi7Tsuneaki Gomi8Takaaki Oizumi9Junko Nagai10Yoshihiro Uesawa11Koichi Takao12Yoshiaki Sugita13Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Pediatric Dentistry, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Pediatric Dentistry, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Orthodontics, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of First Oral and Maxillofacial Surgery, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanDivision of Oral Health, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, JapanMasuko Memorial Hospital, 35-28 Takehashi-cho, Nakamura-ku, Nagoya 453-8566, JapanEcopale Co., Ltd., 885 Minamiisshiki, Nagaizumi-cho, Suntou-gun, Shizuoka 411-0932, JapanGomi clinic, 1-10-12 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, JapanDaiwa Biological Research Institute Co., Ltd., 3-2-1 Sakado, Takatsu-ku, Kawasaki, Kanagawa 213-0012, JapanDepartment of Medical Molecular Informatics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, JapanDepartment of Medical Molecular Informatics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, JapanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Saitama 350-0295, JapanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Sakado, Saitama 350-0295, JapanThe present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous cell carcinoma cell lines, with much lower toxicity against human oral keratinocytes, as compared with various anticancer drugs. QSAR analysis suggests the possible correlation between their tumor-specificity and three-dimensional molecular shape. Condensed tannins in the tea extracts inactivated the glucosyltransferase enzymes, involved in the biofilm formation. Lignin-carbohydrate complexes (prepared by alkaline extraction and acid-precipitation) and crude alkaline extract of the leaves of Sasa species (SE, available as an over-the-counter drug) showed much higher anti-HIV activity, than tannins, flavonoids and Japanese traditional medicine (Kampo). Long-term treatment with SE and several Kampo medicines showed an anti-inflammatory and anti-oxidant effects in small size of clinical trials. Although the anti-periodontitis activity of synthetic angiotensin II blockers has been suggested in many papers, natural angiotensin II blockers has not yet been tested for their possible anti-periodontitis activity. There should be still many unknown substances that are useful for treating the oral diseases in the natural kingdom.http://www.mdpi.com/2305-6320/6/1/4polyphenolchromonelignin-carbohydrate complexalkaline extractKampo medicineglucosyltransferaseangiotensin II blockerQSAR analysisoral diseasesdental application |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroshi Sakagami Taihei Watanabe Tomonori Hoshino Naoto Suda Kazumasa Mori Toshikazu Yasui Naoki Yamauchi Harutsugu Kashiwagi Tsuneaki Gomi Takaaki Oizumi Junko Nagai Yoshihiro Uesawa Koichi Takao Yoshiaki Sugita |
spellingShingle |
Hiroshi Sakagami Taihei Watanabe Tomonori Hoshino Naoto Suda Kazumasa Mori Toshikazu Yasui Naoki Yamauchi Harutsugu Kashiwagi Tsuneaki Gomi Takaaki Oizumi Junko Nagai Yoshihiro Uesawa Koichi Takao Yoshiaki Sugita Recent Progress of Basic Studies of Natural Products and Their Dental Application Medicines polyphenol chromone lignin-carbohydrate complex alkaline extract Kampo medicine glucosyltransferase angiotensin II blocker QSAR analysis oral diseases dental application |
author_facet |
Hiroshi Sakagami Taihei Watanabe Tomonori Hoshino Naoto Suda Kazumasa Mori Toshikazu Yasui Naoki Yamauchi Harutsugu Kashiwagi Tsuneaki Gomi Takaaki Oizumi Junko Nagai Yoshihiro Uesawa Koichi Takao Yoshiaki Sugita |
author_sort |
Hiroshi Sakagami |
title |
Recent Progress of Basic Studies of Natural Products and Their Dental Application |
title_short |
Recent Progress of Basic Studies of Natural Products and Their Dental Application |
title_full |
Recent Progress of Basic Studies of Natural Products and Their Dental Application |
title_fullStr |
Recent Progress of Basic Studies of Natural Products and Their Dental Application |
title_full_unstemmed |
Recent Progress of Basic Studies of Natural Products and Their Dental Application |
title_sort |
recent progress of basic studies of natural products and their dental application |
publisher |
MDPI AG |
series |
Medicines |
issn |
2305-6320 |
publishDate |
2018-12-01 |
description |
The present article reviews the research progress of three major polyphenols (tannins, flavonoids and lignin carbohydrate complexes), chromone (backbone structure of flavonoids) and herbal extracts. Chemical modified chromone derivatives showed highly specific toxicity against human oral squamous cell carcinoma cell lines, with much lower toxicity against human oral keratinocytes, as compared with various anticancer drugs. QSAR analysis suggests the possible correlation between their tumor-specificity and three-dimensional molecular shape. Condensed tannins in the tea extracts inactivated the glucosyltransferase enzymes, involved in the biofilm formation. Lignin-carbohydrate complexes (prepared by alkaline extraction and acid-precipitation) and crude alkaline extract of the leaves of Sasa species (SE, available as an over-the-counter drug) showed much higher anti-HIV activity, than tannins, flavonoids and Japanese traditional medicine (Kampo). Long-term treatment with SE and several Kampo medicines showed an anti-inflammatory and anti-oxidant effects in small size of clinical trials. Although the anti-periodontitis activity of synthetic angiotensin II blockers has been suggested in many papers, natural angiotensin II blockers has not yet been tested for their possible anti-periodontitis activity. There should be still many unknown substances that are useful for treating the oral diseases in the natural kingdom. |
topic |
polyphenol chromone lignin-carbohydrate complex alkaline extract Kampo medicine glucosyltransferase angiotensin II blocker QSAR analysis oral diseases dental application |
url |
http://www.mdpi.com/2305-6320/6/1/4 |
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