Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia
Educational attainment and schizophrenia have a negative phenotypic relationship but show positive genetic correlation. Here, the authors study genetic dependence between the two traits and find that multiple genes have pleiotropic effects on both without a systematic pattern of sign concordance.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05510-z |
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doaj-55c327660abc4980b3af8b9db2eaa44a2021-05-11T09:35:20ZengNature Publishing GroupNature Communications2041-17232018-08-019111210.1038/s41467-018-05510-zGenome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophreniaV. Bansal0M. Mitjans1C. A. P. Burik2R. K. Linnér3A. Okbay4C. A. Rietveld5M. Begemann6S. Bonn7S. Ripke8R. de Vlaming9M. G. Nivard10H. Ehrenreich11P. D. Koellinger12Clinical Neuroscience, Max Planck Institute of Experimental MedicineClinical Neuroscience, Max Planck Institute of Experimental MedicineComplex Trait Genetics, Vrije Universiteit AmsterdamComplex Trait Genetics, Vrije Universiteit AmsterdamComplex Trait Genetics, Vrije Universiteit AmsterdamInstitute for Behavior and Biology, Erasmus University RotterdamClinical Neuroscience, Max Planck Institute of Experimental MedicineResearch Group for Computational Systems Biology, German Center for Neurodegenerative Diseases (DZNE)Analytic and Translational Genetics Unit, Massachusetts General HospitalComplex Trait Genetics, Vrije Universiteit AmsterdamDepartment of Biological Psychology, Vrije Universiteit AmsterdamClinical Neuroscience, Max Planck Institute of Experimental MedicineComplex Trait Genetics, Vrije Universiteit AmsterdamEducational attainment and schizophrenia have a negative phenotypic relationship but show positive genetic correlation. Here, the authors study genetic dependence between the two traits and find that multiple genes have pleiotropic effects on both without a systematic pattern of sign concordance.https://doi.org/10.1038/s41467-018-05510-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
V. Bansal M. Mitjans C. A. P. Burik R. K. Linnér A. Okbay C. A. Rietveld M. Begemann S. Bonn S. Ripke R. de Vlaming M. G. Nivard H. Ehrenreich P. D. Koellinger |
| spellingShingle |
V. Bansal M. Mitjans C. A. P. Burik R. K. Linnér A. Okbay C. A. Rietveld M. Begemann S. Bonn S. Ripke R. de Vlaming M. G. Nivard H. Ehrenreich P. D. Koellinger Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia Nature Communications |
| author_facet |
V. Bansal M. Mitjans C. A. P. Burik R. K. Linnér A. Okbay C. A. Rietveld M. Begemann S. Bonn S. Ripke R. de Vlaming M. G. Nivard H. Ehrenreich P. D. Koellinger |
| author_sort |
V. Bansal |
| title |
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia |
| title_short |
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia |
| title_full |
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia |
| title_fullStr |
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia |
| title_full_unstemmed |
Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia |
| title_sort |
genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Educational attainment and schizophrenia have a negative phenotypic relationship but show positive genetic correlation. Here, the authors study genetic dependence between the two traits and find that multiple genes have pleiotropic effects on both without a systematic pattern of sign concordance. |
| url |
https://doi.org/10.1038/s41467-018-05510-z |
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