Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia
Educational attainment and schizophrenia have a negative phenotypic relationship but show positive genetic correlation. Here, the authors study genetic dependence between the two traits and find that multiple genes have pleiotropic effects on both without a systematic pattern of sign concordance.
Main Authors: | V. Bansal, M. Mitjans, C. A. P. Burik, R. K. Linnér, A. Okbay, C. A. Rietveld, M. Begemann, S. Bonn, S. Ripke, R. de Vlaming, M. G. Nivard, H. Ehrenreich, P. D. Koellinger |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05510-z |
Similar Items
-
Educational attainment: a genome wide association study in 9538 Australians.
by: Nicolas W Martin, et al.
Published: (2011-01-01) -
Effect of Paliperidone Palmitate 3-Month Formulation on Goal Attainment and Disability After 52 Weeks’ Treatment in Patients with Clinically Stable Schizophrenia
by: Lambert M, et al.
Published: (2020-12-01) -
Genetic variation associated with differential educational attainment in adults has anticipated associations with school performance in children.
by: Mary E Ward, et al.
Published: (2014-01-01) -
Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.
by: Ronald de Vlaming, et al.
Published: (2017-01-01) -
Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment.
by: Laura Whitton, et al.
Published: (2018-07-01)