Advanced Flow Cytometry Assays for Immune Monitoring of CAR-T Cell Applications

Advanced Flow Cytometry Assays for Immune Monitoring of CAR-T Cell Applications

Adoptive immunotherapy using chimeric antigen receptor (CAR)-T cells has achieved successful remissions in refractory B-cell leukemia and B-cell lymphomas. In order to estimate both success and severe side effects of CAR-T cell therapies, longitudinal monitoring of the patient’s immune system includ...

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Bibliographic Details
Main Authors: Ulrich Blache, Ronald Weiss, Andreas Boldt, Michael Kapinsky, André-René Blaudszun, Andrea Quaiser, Annabelle Pohl, Tewfik Miloud, Mégane Burgaud, Vladan Vucinic, Uwe Platzbecker, Ulrich Sack, Stephan Fricke, Ulrike Koehl
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
CAR-T
CD19
immune profiling
antibody
flow cytometry
staining technology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.658314/full

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