Potential of oncolytic viruses in the treatment of multiple myeloma
Eric Bartee Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA Abstract: Multiple myeloma (MM) is a clonal malignancy of plasma cells that is newly diagnosed in ~30,000 patients in the US each year. While recently developed therapies have improved th...
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doaj-55cd6e8df6354d8087531ae9ba31317c2020-11-24T22:21:27ZengDove Medical PressOncolytic Virotherapy2253-15722018-02-01Volume 711236928Potential of oncolytic viruses in the treatment of multiple myelomaBartee EEric Bartee Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA Abstract: Multiple myeloma (MM) is a clonal malignancy of plasma cells that is newly diagnosed in ~30,000 patients in the US each year. While recently developed therapies have improved the prognosis for MM patients, relapse rates remain unacceptably high. To overcome this challenge, researchers have begun to investigate the therapeutic potential of oncolytic viruses as a novel treatment option for MM. Preclinical work with these viruses has demonstrated that their infection can be highly specific for MM cells and results in impressive therapeutic efficacy in a variety of preclinical models. This has led to the recent initiation of several human trials. This review summarizes the current state of oncolytic therapy as a therapeutic option for MM and highlights a variety of areas that need to be addressed as the field moves forward. Keywords: oncolytic virotherapy, multiple myeloma, review https://www.dovepress.com/potential-of-oncolytic-viruses-in-the-treatment-of-multiple-myeloma-peer-reviewed-article-OVoncolytic virotherapymultiple myelomareview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bartee E |
spellingShingle |
Bartee E Potential of oncolytic viruses in the treatment of multiple myeloma Oncolytic Virotherapy oncolytic virotherapy multiple myeloma review |
author_facet |
Bartee E |
author_sort |
Bartee E |
title |
Potential of oncolytic viruses in the treatment of multiple myeloma |
title_short |
Potential of oncolytic viruses in the treatment of multiple myeloma |
title_full |
Potential of oncolytic viruses in the treatment of multiple myeloma |
title_fullStr |
Potential of oncolytic viruses in the treatment of multiple myeloma |
title_full_unstemmed |
Potential of oncolytic viruses in the treatment of multiple myeloma |
title_sort |
potential of oncolytic viruses in the treatment of multiple myeloma |
publisher |
Dove Medical Press |
series |
Oncolytic Virotherapy |
issn |
2253-1572 |
publishDate |
2018-02-01 |
description |
Eric Bartee Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA Abstract: Multiple myeloma (MM) is a clonal malignancy of plasma cells that is newly diagnosed in ~30,000 patients in the US each year. While recently developed therapies have improved the prognosis for MM patients, relapse rates remain unacceptably high. To overcome this challenge, researchers have begun to investigate the therapeutic potential of oncolytic viruses as a novel treatment option for MM. Preclinical work with these viruses has demonstrated that their infection can be highly specific for MM cells and results in impressive therapeutic efficacy in a variety of preclinical models. This has led to the recent initiation of several human trials. This review summarizes the current state of oncolytic therapy as a therapeutic option for MM and highlights a variety of areas that need to be addressed as the field moves forward. Keywords: oncolytic virotherapy, multiple myeloma, review |
topic |
oncolytic virotherapy multiple myeloma review |
url |
https://www.dovepress.com/potential-of-oncolytic-viruses-in-the-treatment-of-multiple-myeloma-peer-reviewed-article-OV |
work_keys_str_mv |
AT barteee potentialofoncolyticvirusesinthetreatmentofmultiplemyeloma |
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