Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial

Abstract Introduction: The most prevalent type of arthritis is osteoarthritis which is known with the degenerative knee disease. Limited pieces of evidence have indicated that satureja with special phenol compounds is effective in inflammation reduction and pain alleviation. The aim of this study wa...

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Main Authors: Hassan Mozaffari-Khosravi, Maryam Asadi, Ali Dehghan, Hossein Soleimani Salehabadi, Mohammad Reza Sobhan Ardakani, Mohammad Hossein Fallahzadeh Abarghoui
Format: Article
Language:English
Published: Shahid Sadoughi University of Medical Sciences 2015-09-01
Series:Journal of Community Health Research
Subjects:
Online Access:http://jhr.ssu.ac.ir/browse.php?a_code=A-10-1-127&slc_lang=en&sid=1
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spelling doaj-55d1785714eb4a54a928e288d1bdf45a2020-11-24T22:35:57ZengShahid Sadoughi University of Medical SciencesJournal of Community Health Research2322-56882345-26092015-09-0142148158Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical TrialHassan Mozaffari-Khosravi0Maryam Asadi1Ali Dehghan2Hossein Soleimani Salehabadi3Mohammad Reza Sobhan Ardakani4Mohammad Hossein Fallahzadeh Abarghoui5 1. Department of Nutrition, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Abstract Introduction: The most prevalent type of arthritis is osteoarthritis which is known with the degenerative knee disease. Limited pieces of evidence have indicated that satureja with special phenol compounds is effective in inflammation reduction and pain alleviation. The aim of this study was to investigate the effect of Satureja Hortensis powder supplement on pain improvement and serum TNF-α in patients with knee osteoarthritis(OA). Materials and Methods: The present study was conducted as a placebo-controlled double-blind randomized clinical trial. 39 patients with OA with medium pain were randomly divided into two groups which received Satureja Hortensis powder(SG) and placebo(PG) These groups consumed three 200 mg capsules with the same size and form for two months which contained Satureja Hortensis powder and starch, respectively. Pain intensity was determined using visual analogue scale(VAS) at the beginning and end of the trial. Response to the treatment was defined as pain reduction by more than 1.5 scores. The concentration of TNF-α were measured with ELISA kit. Results: To distribute pain intensity before the intervention, there was no significant difference between the two groups. Before the intervention, all people had a pain score between 4 and 7. After the intervention, 95% of the SG and 84% of the PG were in this scope. These changes were not statistically different(p=0.12). There was no significant difference between the two groups in concentration of TNF-α before and after the intervention. Conclusion: Results of this study showed that Satureja Hortensis powder supplement with dose of 600 mg per day for 60 days was not effective on pain alleviation and concentration of TNF-α in patients with knee osteoarthritis.http://jhr.ssu.ac.ir/browse.php?a_code=A-10-1-127&slc_lang=en&sid=1 Satureja Hortensis Osteoarthritis Pain TNF-α
collection DOAJ
language English
format Article
sources DOAJ
author Hassan Mozaffari-Khosravi
Maryam Asadi
Ali Dehghan
Hossein Soleimani Salehabadi
Mohammad Reza Sobhan Ardakani
Mohammad Hossein Fallahzadeh Abarghoui
spellingShingle Hassan Mozaffari-Khosravi
Maryam Asadi
Ali Dehghan
Hossein Soleimani Salehabadi
Mohammad Reza Sobhan Ardakani
Mohammad Hossein Fallahzadeh Abarghoui
Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
Journal of Community Health Research
Satureja Hortensis
Osteoarthritis
Pain
TNF-α
author_facet Hassan Mozaffari-Khosravi
Maryam Asadi
Ali Dehghan
Hossein Soleimani Salehabadi
Mohammad Reza Sobhan Ardakani
Mohammad Hossein Fallahzadeh Abarghoui
author_sort Hassan Mozaffari-Khosravi
title Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
title_short Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
title_full Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
title_fullStr Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
title_full_unstemmed Effect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
title_sort effect of satureja hortensis powder supplementation on pain and tnf-α in patients with knee osteoarthritis: a double-blind randomized clinical trial
publisher Shahid Sadoughi University of Medical Sciences
series Journal of Community Health Research
issn 2322-5688
2345-2609
publishDate 2015-09-01
description Abstract Introduction: The most prevalent type of arthritis is osteoarthritis which is known with the degenerative knee disease. Limited pieces of evidence have indicated that satureja with special phenol compounds is effective in inflammation reduction and pain alleviation. The aim of this study was to investigate the effect of Satureja Hortensis powder supplement on pain improvement and serum TNF-α in patients with knee osteoarthritis(OA). Materials and Methods: The present study was conducted as a placebo-controlled double-blind randomized clinical trial. 39 patients with OA with medium pain were randomly divided into two groups which received Satureja Hortensis powder(SG) and placebo(PG) These groups consumed three 200 mg capsules with the same size and form for two months which contained Satureja Hortensis powder and starch, respectively. Pain intensity was determined using visual analogue scale(VAS) at the beginning and end of the trial. Response to the treatment was defined as pain reduction by more than 1.5 scores. The concentration of TNF-α were measured with ELISA kit. Results: To distribute pain intensity before the intervention, there was no significant difference between the two groups. Before the intervention, all people had a pain score between 4 and 7. After the intervention, 95% of the SG and 84% of the PG were in this scope. These changes were not statistically different(p=0.12). There was no significant difference between the two groups in concentration of TNF-α before and after the intervention. Conclusion: Results of this study showed that Satureja Hortensis powder supplement with dose of 600 mg per day for 60 days was not effective on pain alleviation and concentration of TNF-α in patients with knee osteoarthritis.
topic Satureja Hortensis
Osteoarthritis
Pain
TNF-α
url http://jhr.ssu.ac.ir/browse.php?a_code=A-10-1-127&slc_lang=en&sid=1
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