Multi-layered tissue head phantoms for noninvasive optical diagnostics
Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known...
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doaj-55e3e4751a2e43e5bf8907d3ebeb1f362020-11-24T22:07:33ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052015-05-01831541005-11541005-1010.1142/S179354581541005910.1142/S1793545815410059Multi-layered tissue head phantoms for noninvasive optical diagnosticsM. S. Wróbel0A. P. Popov1A. V. Bykov2M. Kinnunen3M. Jędrzejewska-Szczerska4V. V. Tuchin5Department of Metrology and Optoelectronics, Gdańsk University of Technology, Gabriela Narutowicza Street 11/12, 80-233 Gdańsk, PolandOptoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, FinlandOptoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, FinlandOptoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, FinlandDepartment of Metrology and Optoelectronics, Gdańsk University of Technology, Gabriela Narutowicza Street 11/12, 80-233 Gdańsk, PolandOptoelectronics and Measurement Techniques Laboratory, Faculty of Information Technology and Electrical Engineering, University of Oulu, P. O. Box 4500, FI-90014 Oulu, FinlandExtensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient $\mu_{s}^{\prime}$ and absorption coefficient μa) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide (ZnO) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature.http://www.worldscientific.com/doi/pdf/10.1142/S1793545815410059Tissue-mimicking phantomsoptical propertiesnear-infrared spectroscopyhead model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. S. Wróbel A. P. Popov A. V. Bykov M. Kinnunen M. Jędrzejewska-Szczerska V. V. Tuchin |
spellingShingle |
M. S. Wróbel A. P. Popov A. V. Bykov M. Kinnunen M. Jędrzejewska-Szczerska V. V. Tuchin Multi-layered tissue head phantoms for noninvasive optical diagnostics Journal of Innovative Optical Health Sciences Tissue-mimicking phantoms optical properties near-infrared spectroscopy head model |
author_facet |
M. S. Wróbel A. P. Popov A. V. Bykov M. Kinnunen M. Jędrzejewska-Szczerska V. V. Tuchin |
author_sort |
M. S. Wróbel |
title |
Multi-layered tissue head phantoms for noninvasive optical diagnostics |
title_short |
Multi-layered tissue head phantoms for noninvasive optical diagnostics |
title_full |
Multi-layered tissue head phantoms for noninvasive optical diagnostics |
title_fullStr |
Multi-layered tissue head phantoms for noninvasive optical diagnostics |
title_full_unstemmed |
Multi-layered tissue head phantoms for noninvasive optical diagnostics |
title_sort |
multi-layered tissue head phantoms for noninvasive optical diagnostics |
publisher |
World Scientific Publishing |
series |
Journal of Innovative Optical Health Sciences |
issn |
1793-5458 1793-7205 |
publishDate |
2015-05-01 |
description |
Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient $\mu_{s}^{\prime}$ and absorption coefficient μa) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide (ZnO) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature. |
topic |
Tissue-mimicking phantoms optical properties near-infrared spectroscopy head model |
url |
http://www.worldscientific.com/doi/pdf/10.1142/S1793545815410059 |
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