Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq
During the period from February 2013 to April 2014, 74 (12.3%) isolates of Streptococcus pneumoniae were isolated from 600 patients (359 males and 241 females) with clinical symptoms of Lower respiratory tract infections (LRTI) (pneumonia and COPD) obtained from Najaf/Iraq Hospitals. Patients in the...
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doaj-55edbab7bb6741668098c8787355ade52021-09-05T20:44:53ZengSciendoEnvironmental & Socio-economic Studies2354-00792017-06-0152101810.1515/environ-2017-0007environ-2017-0007Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, IraqMotaweq Zahraa Y.0Naher Habeeb S.1Department of Biology, College of Science, Kufa University, Najaf, IraqDepartment of Microbiology, College of Medicine, Babylon University, Najaf, IraqDuring the period from February 2013 to April 2014, 74 (12.3%) isolates of Streptococcus pneumoniae were isolated from 600 patients (359 males and 241 females) with clinical symptoms of Lower respiratory tract infections (LRTI) (pneumonia and COPD) obtained from Najaf/Iraq Hospitals. Patients in the age groups 51-60 years had a high percentage of S. pneumoniae isolates (19.7%) compared with other age groups with a significant variation (P<0.05) between them. Males (54%) showed a higher percentage of S. pneumoniae isolates than females (45.9%) with no significant variation (P>0.05). Smokers have been shown to have increased risk to LRTI than non-smokers (P>0.05), and there was no significant variation between Urban and Rural (56.8:43.2%) patients. S. pneumoniae showed different susceptibilities towards antibiotics used in this study. The highest rate of resistance was against erythromycin (100%), azithromycin (83.8%), clindamycin (83.8%) and trimethoprim/sulfamethaxzol (81.1%) and moderate resistance to ceftriaxone (67.6%), cefotaxime (64.9%), chloramphenicol (64.9%), tetracycline (59.5%) and benzylpenicillin (45.9%) whereas there was a relatively lower resistance towards others. The results of this study showed that S. pneumoniae isolates were found to be remarkable sensitive to Vancomycin (100%) and Imipenem (100%). In this study, sixteen antibiotics were tested for (MIC) against 37 S. pneumoniae isolates by using Vitek-2 antibiotic susceptibility testing (AST) cards (41497) AST-GP74. 100% and 83.8% of S. pneumoniae isolates were resistant to erythromycin and SXT with MIC ≥1 mg/ml and 4/76 mg/ml of these antibiotic respectively, and moderately resistant to cefotaxime 64.9%, ceftriaxone 64.9% and chloramphenicol 64.9% with MIC 4 mg/ml for CTX and CRO each one, and MIC 8 mg/ml for C only. All isolates showed 100% sensitivity for each of Vancomycin and Erythromycin with MIC mg/ml and ≤1 mg/ml and ≤2 mg/ml, respectively. S. pneumoniae isolates showed a high rate of sensitivity to Ertapenem 97.3% with MIC ≤1 mg/ml, Telithromycin 89.2% with MIC ≤1, Meropenem 86.5% with MIC ≤0.25 mg/ml.https://doi.org/10.1515/environ-2017-0007streptococcus pneumoniaeantibiotic resistancelower respiratory tract infections (lrti)minimum inhibitory concentration (mic)copd |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Motaweq Zahraa Y. Naher Habeeb S. |
spellingShingle |
Motaweq Zahraa Y. Naher Habeeb S. Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq Environmental & Socio-economic Studies streptococcus pneumoniae antibiotic resistance lower respiratory tract infections (lrti) minimum inhibitory concentration (mic) copd |
author_facet |
Motaweq Zahraa Y. Naher Habeeb S. |
author_sort |
Motaweq Zahraa Y. |
title |
Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq |
title_short |
Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq |
title_full |
Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq |
title_fullStr |
Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq |
title_full_unstemmed |
Antimicrobial susceptibility of Streptococcus pneumoniae isolates causing LRTI in Najaf, Iraq |
title_sort |
antimicrobial susceptibility of streptococcus pneumoniae isolates causing lrti in najaf, iraq |
publisher |
Sciendo |
series |
Environmental & Socio-economic Studies |
issn |
2354-0079 |
publishDate |
2017-06-01 |
description |
During the period from February 2013 to April 2014, 74 (12.3%) isolates of Streptococcus pneumoniae were isolated from 600 patients (359 males and 241 females) with clinical symptoms of Lower respiratory tract infections (LRTI) (pneumonia and COPD) obtained from Najaf/Iraq Hospitals. Patients in the age groups 51-60 years had a high percentage of S. pneumoniae isolates (19.7%) compared with other age groups with a significant variation (P<0.05) between them. Males (54%) showed a higher percentage of S. pneumoniae isolates than females (45.9%) with no significant variation (P>0.05). Smokers have been shown to have increased risk to LRTI than non-smokers (P>0.05), and there was no significant variation between Urban and Rural (56.8:43.2%) patients. S. pneumoniae showed different susceptibilities towards antibiotics used in this study. The highest rate of resistance was against erythromycin (100%), azithromycin (83.8%), clindamycin (83.8%) and trimethoprim/sulfamethaxzol (81.1%) and moderate resistance to ceftriaxone (67.6%), cefotaxime (64.9%), chloramphenicol (64.9%), tetracycline (59.5%) and benzylpenicillin (45.9%) whereas there was a relatively lower resistance towards others. The results of this study showed that S. pneumoniae isolates were found to be remarkable sensitive to Vancomycin (100%) and Imipenem (100%). In this study, sixteen antibiotics were tested for (MIC) against 37 S. pneumoniae isolates by using Vitek-2 antibiotic susceptibility testing (AST) cards (41497) AST-GP74. 100% and 83.8% of S. pneumoniae isolates were resistant to erythromycin and SXT with MIC ≥1 mg/ml and 4/76 mg/ml of these antibiotic respectively, and moderately resistant to cefotaxime 64.9%, ceftriaxone 64.9% and chloramphenicol 64.9% with MIC 4 mg/ml for CTX and CRO each one, and MIC 8 mg/ml for C only. All isolates showed 100% sensitivity for each of Vancomycin and Erythromycin with MIC mg/ml and ≤1 mg/ml and ≤2 mg/ml, respectively. S. pneumoniae isolates showed a high rate of sensitivity to Ertapenem 97.3% with MIC ≤1 mg/ml, Telithromycin 89.2% with MIC ≤1, Meropenem 86.5% with MIC ≤0.25 mg/ml. |
topic |
streptococcus pneumoniae antibiotic resistance lower respiratory tract infections (lrti) minimum inhibitory concentration (mic) copd |
url |
https://doi.org/10.1515/environ-2017-0007 |
work_keys_str_mv |
AT motaweqzahraay antimicrobialsusceptibilityofstreptococcuspneumoniaeisolatescausinglrtiinnajafiraq AT naherhabeebs antimicrobialsusceptibilityofstreptococcuspneumoniaeisolatescausinglrtiinnajafiraq |
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