Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy

Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy

Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) diss...

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Main Authors: Robynn Lester, Deirdre Church, Anshula Ambasta
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Medical Mycology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221175391930048X
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spelling doaj-55f448c017634e3ca2587df42a7e15622020-11-25T03:43:01ZengElsevierMedical Mycology Case Reports2211-75392019-09-01252528Disseminated cerebral aspergillosis complicated by thrombotic microangiopathyRobynn Lester0Deirdre Church1Anshula Ambasta2Cumming School of Medicine, University of Calgary, Calgary, Alberta, CanadaCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Pathology & Laboratory Medicine and Medicine, University of Calgary, Calgary, Alberta, CanadaCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Ward of the 21st Century, University of Calgary, Calgary, Alberta, Canada; Corresponding author. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) disseminated IA has not been described in anti-glomerular basement membrane glomerulonephritis; 2) IA led to thrombotic microangiopathy with normal ADAMTS13 and 3) voriconazole toxicity necessitated use of isavuconazole for IA treatment. Keywords: Invasive aspergillosis, Cerebral aspergillosis, Thrombotic microangiopathy, Voriconazole-induced periostitis, Isavuconazolehttp://www.sciencedirect.com/science/article/pii/S221175391930048X
collection DOAJ
language English
format Article
sources DOAJ
author Robynn Lester
Deirdre Church
Anshula Ambasta
spellingShingle Robynn Lester
Deirdre Church
Anshula Ambasta
Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
Medical Mycology Case Reports
author_facet Robynn Lester
Deirdre Church
Anshula Ambasta
author_sort Robynn Lester
title Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_short Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_full Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_fullStr Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_full_unstemmed Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_sort disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
publisher Elsevier
series Medical Mycology Case Reports
issn 2211-7539
publishDate 2019-09-01
description Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) disseminated IA has not been described in anti-glomerular basement membrane glomerulonephritis; 2) IA led to thrombotic microangiopathy with normal ADAMTS13 and 3) voriconazole toxicity necessitated use of isavuconazole for IA treatment. Keywords: Invasive aspergillosis, Cerebral aspergillosis, Thrombotic microangiopathy, Voriconazole-induced periostitis, Isavuconazole
url http://www.sciencedirect.com/science/article/pii/S221175391930048X
work_keys_str_mv AT robynnlester disseminatedcerebralaspergillosiscomplicatedbythromboticmicroangiopathy
AT deirdrechurch disseminatedcerebralaspergillosiscomplicatedbythromboticmicroangiopathy
AT anshulaambasta disseminatedcerebralaspergillosiscomplicatedbythromboticmicroangiopathy
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