Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.

Bibliographic Details
Main Authors:	Sharan Paul, Warunee Dansithong, Karla P. Figueroa, Daniel R. Scoles, Stefan M. Pulst
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06041-3

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spelling	doaj-55f49f6a513e4819a5bfa825f7bb68a42021-05-11T10:27:54ZengNature Publishing GroupNature Communications2041-17232018-09-019111410.1038/s41467-018-06041-3Staufen1 links RNA stress granules and autophagy in a model of neurodegenerationSharan Paul0Warunee Dansithong1Karla P. Figueroa2Daniel R. Scoles3Stefan M. Pulst4Department of Neurology, University of UtahDepartment of Neurology, University of UtahDepartment of Neurology, University of UtahDepartment of Neurology, University of UtahDepartment of Neurology, University of UtahSpinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.https://doi.org/10.1038/s41467-018-06041-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sharan Paul Warunee Dansithong Karla P. Figueroa Daniel R. Scoles Stefan M. Pulst
spellingShingle	Sharan Paul Warunee Dansithong Karla P. Figueroa Daniel R. Scoles Stefan M. Pulst Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration Nature Communications
author_facet	Sharan Paul Warunee Dansithong Karla P. Figueroa Daniel R. Scoles Stefan M. Pulst
author_sort	Sharan Paul
title	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_short	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_full	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_fullStr	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_full_unstemmed	Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration
title_sort	staufen1 links rna stress granules and autophagy in a model of neurodegeneration
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2.
url	https://doi.org/10.1038/s41467-018-06041-3
work_keys_str_mv	AT sharanpaul staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT waruneedansithong staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT karlapfigueroa staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT danielrscoles staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration AT stefanmpulst staufen1linksrnastressgranulesandautophagyinamodelofneurodegeneration
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Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

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