A Comparative Study of Rat Urine <sup>1</sup>H-NMR Metabolome Changes Presumably Arising from Isoproterenol-Induced Heart Necrosis Versus Clarithromycin-Induced QT Interval Prolongation

A Comparative Study of Rat Urine <sup>1</sup>H-NMR Metabolome Changes Presumably Arising from Isoproterenol-Induced Heart Necrosis Versus Clarithromycin-Induced QT Interval Prolongation

Cardiotoxicity remains a challenging concern both in drug development and in the management of various clinical situations. There are a lot of examples of drugs withdrawn from the market or stopped during clinical trials due to unpredicted cardiac adverse events. Obviously, current conventional meth...

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Bibliographic Details
Main Authors: Matthieu Dallons, Manon Delcourt, Corentin Schepkens, Manuel Podrecca, Jean-Marie Colet
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biology
Subjects:
isoproterenol
clarithromycin
urine
metabonomics
<sup>1</sup>H-NMR
biomarker
Online Access:https://www.mdpi.com/2079-7737/9/5/98

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