Cytodenic characteristics of patients with brain tumors under treatment by verapamilum and ketamine in vitro

• Main Authors: T V Fedoronchuk, S P Syatkin, V A Frolov, N Ya Gridina, I V Boltina
• Format: Article
• Language: English
• Published: Peoples’ Friendship University of Russia (RUDN University) 2012-09-01
• Series: RUDN Journal of Medicine
• Subjects: кетамин; верапамил; аберрации хромосом; анеуплоидные и полиплоидные клетки; опухоли головного мозга
• Online Access: http://journals.rudn.ru/medicine/article/view/3605

There are results of analyzing of cytogenetic characteristics of patients with brain tumors under treatment by Verapamilum and Ketamine in vitro. Under the Verapamilum action it was shown sure decreasing of the chromosome aberrations frequencies just like decreasing of the aneuploid and polyploid cells quantity in patient's malignant tumors. It also was shown the substantial reduction in aneuploid cells number among tests of patients with malignant tumors under Ketamine exposure. Patients with benign or malignant tumors had the very lowest magnitudes of multyaberratic cells amount and of the extent of aberratic cell injury under the Verapamilum influence.