Imatinib dose optimisation following the disease progression in a patient with metastatic GIST
Here we report a case of a man affected by metastatic GIST since march 2007. His oncologic history began in 2006 when he was submitted to ileal resection and diagnosis of abdominal GIST was made. He was free of disease at radiologic controls until march 2007, when peritoneal nodules were shown. He s...
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doaj-5628c61c6b5a4df1914cab984f8668e02020-11-24T21:07:59ZengSEEdClinical Management Issues1973-48322283-31372015-10-0154S3610.7175/cmi.v5i4S.11231054Imatinib dose optimisation following the disease progression in a patient with metastatic GISTMariangela Parodi0Monica Boitano1Luciano Canobbio2UOS Oncologia Medica, Ospedale P.A. Micone, Genova Sestri PonenteUOS Oncologia Medica, Ospedale P.A. Micone, Genova Sestri PonenteUOS Oncologia Medica, Ospedale P.A. Micone, Genova Sestri PonenteHere we report a case of a man affected by metastatic GIST since march 2007. His oncologic history began in 2006 when he was submitted to ileal resection and diagnosis of abdominal GIST was made. He was free of disease at radiologic controls until march 2007, when peritoneal nodules were shown. He started imatinib as first line therapy at standard dose of 400 mg/day and he reached a partial response at 6 months according to Response Evaluation Criteria In Solid Tumors (RECIST). After 24 months he performed CT scan that showed progression disease. For this reason he increased imatinib dose to 800 mg/day. Imatinib was safely administered and radiologic analysis performed at 3 and 6 months demonstrated stable disease according to RECIST. The patient is continuing oral therapy with imatinib at 800 mg/day and the disease is still stable.https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/1123Metastatic GISTImatinibRECIST |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mariangela Parodi Monica Boitano Luciano Canobbio |
spellingShingle |
Mariangela Parodi Monica Boitano Luciano Canobbio Imatinib dose optimisation following the disease progression in a patient with metastatic GIST Clinical Management Issues Metastatic GIST Imatinib RECIST |
author_facet |
Mariangela Parodi Monica Boitano Luciano Canobbio |
author_sort |
Mariangela Parodi |
title |
Imatinib dose optimisation following the disease progression in a patient with metastatic GIST |
title_short |
Imatinib dose optimisation following the disease progression in a patient with metastatic GIST |
title_full |
Imatinib dose optimisation following the disease progression in a patient with metastatic GIST |
title_fullStr |
Imatinib dose optimisation following the disease progression in a patient with metastatic GIST |
title_full_unstemmed |
Imatinib dose optimisation following the disease progression in a patient with metastatic GIST |
title_sort |
imatinib dose optimisation following the disease progression in a patient with metastatic gist |
publisher |
SEEd |
series |
Clinical Management Issues |
issn |
1973-4832 2283-3137 |
publishDate |
2015-10-01 |
description |
Here we report a case of a man affected by metastatic GIST since march 2007. His oncologic history began in 2006 when he was submitted to ileal resection and diagnosis of abdominal GIST was made. He was free of disease at radiologic controls until march 2007, when peritoneal nodules were shown. He started imatinib as first line therapy at standard dose of 400 mg/day and he reached a partial response at 6 months according to Response Evaluation Criteria In Solid Tumors (RECIST). After 24 months he performed CT scan that showed progression disease. For this reason he increased imatinib dose to 800 mg/day. Imatinib was safely administered and radiologic analysis performed at 3 and 6 months demonstrated stable disease according to RECIST. The patient is continuing oral therapy with imatinib at 800 mg/day and the disease is still stable. |
topic |
Metastatic GIST Imatinib RECIST |
url |
https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/1123 |
work_keys_str_mv |
AT mariangelaparodi imatinibdoseoptimisationfollowingthediseaseprogressioninapatientwithmetastaticgist AT monicaboitano imatinibdoseoptimisationfollowingthediseaseprogressioninapatientwithmetastaticgist AT lucianocanobbio imatinibdoseoptimisationfollowingthediseaseprogressioninapatientwithmetastaticgist |
_version_ |
1716761280831815680 |