Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pitui...
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doaj-562be2630d12427ab35a06fe43fe6a132021-10-02T02:38:42ZengTripoli UniversityOpen Veterinary Journal2218-60502218-60502018-03-01818695http://dx.doi.org/10.4314/ovj.v8i1.14Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticismPatricia N. Vidal0Diego D. Miceli1Elber Soler Arias2Elena D'Anna3Jorge D. García4Victor Alejandro Castillo5Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, Argentina and U. Diagnóstico por Imágenes, Hospital Escuela de Medicina Veterinaria, Argentina and Research fellow of CONICET. Av. Chorroarín 280, (1427) C. A. Buenos Aires, ArgentinaUniversidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, Argentina and U. Diagnóstico por Imágenes, Hospital Escuela de Medicina Veterinaria, Argentina and Research fellow of CONICET. Av. Chorroarín 280, (1427) C. A. Buenos Aires, ArgentinaUniversidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, ArgentinaUniversidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, Argentina and U. Diagnóstico por Imágenes, Hospital Escuela de Medicina Veterinaria, ArgentinaUniversidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, ArgentinaUniversidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Clínica Médica de Pequeños Animales and U. de Endocrinología, ArgentinaHyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r = -0.87; P<0.0001 and r = -0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r = -0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.http://www.openveterinaryjournal.com/OVJ-2017-11-207%20P.N.%20Vidal%20et%20al.pdfBlood pressionHyperadrenocorticism pituitary dependentNitric oxideRenal functionScintigraphy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patricia N. Vidal Diego D. Miceli Elber Soler Arias Elena D'Anna Jorge D. García Victor Alejandro Castillo |
spellingShingle |
Patricia N. Vidal Diego D. Miceli Elber Soler Arias Elena D'Anna Jorge D. García Victor Alejandro Castillo Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism Open Veterinary Journal Blood pression Hyperadrenocorticism pituitary dependent Nitric oxide Renal function Scintigraphy |
author_facet |
Patricia N. Vidal Diego D. Miceli Elber Soler Arias Elena D'Anna Jorge D. García Victor Alejandro Castillo |
author_sort |
Patricia N. Vidal |
title |
Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism |
title_short |
Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism |
title_full |
Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism |
title_fullStr |
Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism |
title_full_unstemmed |
Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism |
title_sort |
decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism |
publisher |
Tripoli University |
series |
Open Veterinary Journal |
issn |
2218-6050 2218-6050 |
publishDate |
2018-03-01 |
description |
Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r = -0.87; P<0.0001 and r = -0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r = -0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage. |
topic |
Blood pression Hyperadrenocorticism pituitary dependent Nitric oxide Renal function Scintigraphy |
url |
http://www.openveterinaryjournal.com/OVJ-2017-11-207%20P.N.%20Vidal%20et%20al.pdf |
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