Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control[S]
Site-1 protease (S1P) cleaves membrane-bound lipogenic sterol regulatory element-binding proteins (SREBPs) and the α/β-subunit precursor protein of the N-acetylglucosamine-1-phosphotransferase forming mannose 6-phosphate (M6P) targeting markers on lysosomal enzymes. The translocation of SREBPs from...
Main Authors: | Sarah Klünder, Jörg Heeren, Sandra Markmann, René Santer, Thomas Braulke, Sandra Pohl |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-08-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520355395 |
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