Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study
BackgroundThe optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that propofol independently reduces migration of cancer cells and metastasis. Thus, the authors retrospectively examined the link be...
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doaj-563500f990da4c67a568e9b77b2826b92020-11-25T03:57:09ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632016-04-0169212613210.4097/kjae.2016.69.2.1268151Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective studyJi Heui Lee0Seok Hee Kang1Yunkwang Kim2Hyun Ah Kim3Bong Seog Kim4Department of Anesthesiology and Pain Medicine, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.Department of General Surgery, Center for Breast Cancer, Korea Cancer Center Hospital, Seoul, Korea.Department of Hemato-oncology, Veterans Health Service Medical Center, Seoul, Korea.BackgroundThe optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that propofol independently reduces migration of cancer cells and metastasis. Thus, the authors retrospectively examined the link between propofol-based total intravenous anesthesia (TIVA) and recurrence or overall survival in patients undergoing modified radical mastectomy (MRM).MethodsA retrospective analysis of the electronic database of all patients undergoing MRM for breast cancer between January 2007 and December 2008 was undertaken. Patients received either propofol-based TIVA (propofol group) or sevoflurane-based anesthesia (sevoflurane group). We analyzed prognostic factors of breast cancer and perioperative factors and compared recurrence-free survival and overall survival between propofol and sevoflurane groups.ResultsA total of 363 MRMs were carried out during the period of the trial; 325 cases were suitable for analysis (173 cases of propofol group, and 152 cases of sevoflurane group). There were insignificant differences between the groups in age, weight, height, histopathologic results, surgical time, or postoperative treatment (chemotherapy, hormonal therapy, and radiotherapy). The use of opioids during the perioperative period was greater in propofol group than in sevoflurane group. Overall survival was no difference between the two groups. Propofol group showed a lower rate of cancer recurrence (P = 0.037), with an estimated hazard ratio of 0.550 (95% CI 0.311–0.973).ConclusionsThis retrospective study provides the possibility that propofol-based TIVA for breast cancer surgery can reduce the risk of recurrence during the initial 5 years after MRM.http://ekja.org/upload/pdf/kjae-69-126.pdfbreast neoplasmspropofolrecurrencesevoflurane |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Heui Lee Seok Hee Kang Yunkwang Kim Hyun Ah Kim Bong Seog Kim |
spellingShingle |
Ji Heui Lee Seok Hee Kang Yunkwang Kim Hyun Ah Kim Bong Seog Kim Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study Korean Journal of Anesthesiology breast neoplasms propofol recurrence sevoflurane |
author_facet |
Ji Heui Lee Seok Hee Kang Yunkwang Kim Hyun Ah Kim Bong Seog Kim |
author_sort |
Ji Heui Lee |
title |
Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study |
title_short |
Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study |
title_full |
Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study |
title_fullStr |
Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study |
title_full_unstemmed |
Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study |
title_sort |
effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study |
publisher |
Korean Society of Anesthesiologists |
series |
Korean Journal of Anesthesiology |
issn |
2005-6419 2005-7563 |
publishDate |
2016-04-01 |
description |
BackgroundThe optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that propofol independently reduces migration of cancer cells and metastasis. Thus, the authors retrospectively examined the link between propofol-based total intravenous anesthesia (TIVA) and recurrence or overall survival in patients undergoing modified radical mastectomy (MRM).MethodsA retrospective analysis of the electronic database of all patients undergoing MRM for breast cancer between January 2007 and December 2008 was undertaken. Patients received either propofol-based TIVA (propofol group) or sevoflurane-based anesthesia (sevoflurane group). We analyzed prognostic factors of breast cancer and perioperative factors and compared recurrence-free survival and overall survival between propofol and sevoflurane groups.ResultsA total of 363 MRMs were carried out during the period of the trial; 325 cases were suitable for analysis (173 cases of propofol group, and 152 cases of sevoflurane group). There were insignificant differences between the groups in age, weight, height, histopathologic results, surgical time, or postoperative treatment (chemotherapy, hormonal therapy, and radiotherapy). The use of opioids during the perioperative period was greater in propofol group than in sevoflurane group. Overall survival was no difference between the two groups. Propofol group showed a lower rate of cancer recurrence (P = 0.037), with an estimated hazard ratio of 0.550 (95% CI 0.311–0.973).ConclusionsThis retrospective study provides the possibility that propofol-based TIVA for breast cancer surgery can reduce the risk of recurrence during the initial 5 years after MRM. |
topic |
breast neoplasms propofol recurrence sevoflurane |
url |
http://ekja.org/upload/pdf/kjae-69-126.pdf |
work_keys_str_mv |
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