A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation

A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation

Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphip...

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Main Authors: Zhuo Chen, Zhinan Fu, Li Li, Enguang Ma, Xuhong Guo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Nanomaterials
Subjects:
flash nanoprecipitation (FNP)
nanoparticle
amphiphilic homopolymer
chitosan
Online Access:https://www.mdpi.com/2079-4991/11/3/734
id doaj-5636687e38f14b06a5db6387f28cd05f
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spelling doaj-5636687e38f14b06a5db6387f28cd05f2021-03-16T00:01:08ZengMDPI AGNanomaterials2079-49912021-03-011173473410.3390/nano11030734A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash NanoprecipitationZhuo Chen0Zhinan Fu1Li Li2Enguang Ma3Xuhong Guo4State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaEngineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832000, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaFlash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.https://www.mdpi.com/2079-4991/11/3/734flash nanoprecipitation (FNP)nanoparticleamphiphilic homopolymerchitosan
collection DOAJ
language English
format Article
sources DOAJ
author Zhuo Chen
Zhinan Fu
Li Li
Enguang Ma
Xuhong Guo
spellingShingle Zhuo Chen
Zhinan Fu
Li Li
Enguang Ma
Xuhong Guo
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
Nanomaterials
flash nanoprecipitation (FNP)
nanoparticle
amphiphilic homopolymer
chitosan
author_facet Zhuo Chen
Zhinan Fu
Li Li
Enguang Ma
Xuhong Guo
author_sort Zhuo Chen
title A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
title_short A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
title_full A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
title_fullStr A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
title_full_unstemmed A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
title_sort cost-effective nano-sized curcumin delivery system with high drug loading capacity prepared via flash nanoprecipitation
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2021-03-01
description Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.
topic flash nanoprecipitation (FNP)
nanoparticle
amphiphilic homopolymer
chitosan
url https://www.mdpi.com/2079-4991/11/3/734
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AT zhinanfu acosteffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT lili acosteffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT enguangma acosteffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT xuhongguo acosteffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT zhuochen costeffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT zhinanfu costeffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT lili costeffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT enguangma costeffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
AT xuhongguo costeffectivenanosizedcurcumindeliverysystemwithhighdrugloadingcapacitypreparedviaflashnanoprecipitation
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