A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation
Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphip...
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doaj-5636687e38f14b06a5db6387f28cd05f2021-03-16T00:01:08ZengMDPI AGNanomaterials2079-49912021-03-011173473410.3390/nano11030734A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash NanoprecipitationZhuo Chen0Zhinan Fu1Li Li2Enguang Ma3Xuhong Guo4State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaEngineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832000, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaFlash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up.https://www.mdpi.com/2079-4991/11/3/734flash nanoprecipitation (FNP)nanoparticleamphiphilic homopolymerchitosan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhuo Chen Zhinan Fu Li Li Enguang Ma Xuhong Guo |
spellingShingle |
Zhuo Chen Zhinan Fu Li Li Enguang Ma Xuhong Guo A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation Nanomaterials flash nanoprecipitation (FNP) nanoparticle amphiphilic homopolymer chitosan |
author_facet |
Zhuo Chen Zhinan Fu Li Li Enguang Ma Xuhong Guo |
author_sort |
Zhuo Chen |
title |
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation |
title_short |
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation |
title_full |
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation |
title_fullStr |
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation |
title_full_unstemmed |
A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation |
title_sort |
cost-effective nano-sized curcumin delivery system with high drug loading capacity prepared via flash nanoprecipitation |
publisher |
MDPI AG |
series |
Nanomaterials |
issn |
2079-4991 |
publishDate |
2021-03-01 |
description |
Flash nanoprecipitation (FNP) is an efficient technique for encapsulating drugs in particulate carriers assembled by amphiphilic polymers. In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent. Using this strategy, high encapsulation efficiency (EE > 95%) and drug loading capacity (DLC > 40%) of CUR were achieved. The resulting CUR-loaded nanoparticles (NPs) showed a long-term stability (at least 2 months) and pH-responsive release behavior. This work offers a new strategy to prepare cost-effective drug-loaded NPs with high drug loading capacity and opens a unique opportunity for industrial scale-up. |
topic |
flash nanoprecipitation (FNP) nanoparticle amphiphilic homopolymer chitosan |
url |
https://www.mdpi.com/2079-4991/11/3/734 |
work_keys_str_mv |
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