Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire
<p>Abstract</p> <p>Background</p> <p>Pyrethroid resistance in vectors could limit the efficacy of long-lasting insecticidal nets (LLINs) because all LLINs are currently treated with pyrethroids. The goal of this study was to evaluate the efficacy and wash resistance of...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2011-06-01
|
Series: | Malaria Journal |
Online Access: | http://www.malariajournal.com/content/10/1/172 |
id |
doaj-5636f01f7eba4558bf987bcaa7e76d24 |
---|---|
record_format |
Article |
spelling |
doaj-5636f01f7eba4558bf987bcaa7e76d242020-11-24T21:27:20ZengBMCMalaria Journal1475-28752011-06-0110117210.1186/1475-2875-10-172Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'IvoireKoffi Alphonsine AKoudou Benjamin GMalone DavidHemingway Janet<p>Abstract</p> <p>Background</p> <p>Pyrethroid resistance in vectors could limit the efficacy of long-lasting insecticidal nets (LLINs) because all LLINs are currently treated with pyrethroids. The goal of this study was to evaluate the efficacy and wash resistance of PermaNet<sup>® </sup>3.0 compared to PermaNet<sup>® </sup>2.0 in an area of high pyrethroid in Côte d'Ivoire. PermaNet<sup>® </sup>3.0 is impregnated with deltamethrin at 85 mg/m<sup>2 </sup>on the sides of the net and with deltamethrin and piperonyl butoxide on the roof. PermaNet<sup>® </sup>2.0 is impregnated with deltamethrin at 55 mg/m<sup>2 </sup>across the entire net.</p> <p>Methods</p> <p>The study was conducted in the station of Yaokoffikro, in central Côte d'Ivoire. The efficacy of intact unwashed and washed LLINs was compared over a 12-week period with a conventionally-treated net (CTN) washed to just before exhaustion. WHO cone bioassays were performed on sub-sections of the nets, using wild-resistant <it>An. gambiae </it>and Kisumu strains. Mosquitoes were collected five days per week and were identified to genus and species level and classified as dead or alive, then unfed or blood-fed.</p> <p>Results</p> <p>Mortality rates of over 80% from cone bioassays with wild-caught pyrethroid-resistant <it>An. gambiae </it>s.s were recorded only with unwashed PermaNet<sup>® </sup>3.0. Over 12 weeks, a total of 7,291 mosquitoes were collected. There were significantly more <it>An. gambiae </it>s.s. and <it>Culex </it>spp. caught in control huts than with other treatments (P < 0.001). The proportion of mosquitoes exiting the huts was significantly lower with the control than for the treatment arms (P < 0.001). Mortality rates with resistant <it>An. gambiae </it>s.s and <it>Culex </it>spp, were lower for the control than for other treatments (P < 0.001), which did not differ (P > 0.05) except for unwashed PermaNet<sup>® </sup>3.0 (P < 0.001), which gave significantly higher mortality (P < 0.001).</p> <p>Conclusions</p> <p>This study showed that unwashed PermaNet<sup>® </sup>3.0 caused significantly higher mortality against pyrethroid resistant <it>An. gambiae s.s </it>and <it>Culex </it>spp than PermaNet<sup>® </sup>2.0 and the CTN. The increased efficacy with unwashed PermaNet<sup>® </sup>3.0 over PermaNet<sup>® </sup>2.0 and the CTN was also demonstrated by higher KD and mortality rates (KD > 95% and mortality rate > 80%) in cone bioassays performed with wild pyrethroid-resistant <it>An. gambiae s.s </it>from Yaokoffikro.</p> http://www.malariajournal.com/content/10/1/172 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koffi Alphonsine A Koudou Benjamin G Malone David Hemingway Janet |
spellingShingle |
Koffi Alphonsine A Koudou Benjamin G Malone David Hemingway Janet Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire Malaria Journal |
author_facet |
Koffi Alphonsine A Koudou Benjamin G Malone David Hemingway Janet |
author_sort |
Koffi Alphonsine A |
title |
Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire |
title_short |
Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire |
title_full |
Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire |
title_fullStr |
Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire |
title_full_unstemmed |
Efficacy of PermaNet<sup>® </sup>2.0 and PermaNet<sup>® </sup>3.0 against insecticide-resistant <it>Anopheles gambiae </it>in experimental huts in Côte d'Ivoire |
title_sort |
efficacy of permanet<sup>® </sup>2.0 and permanet<sup>® </sup>3.0 against insecticide-resistant <it>anopheles gambiae </it>in experimental huts in côte d'ivoire |
publisher |
BMC |
series |
Malaria Journal |
issn |
1475-2875 |
publishDate |
2011-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Pyrethroid resistance in vectors could limit the efficacy of long-lasting insecticidal nets (LLINs) because all LLINs are currently treated with pyrethroids. The goal of this study was to evaluate the efficacy and wash resistance of PermaNet<sup>® </sup>3.0 compared to PermaNet<sup>® </sup>2.0 in an area of high pyrethroid in Côte d'Ivoire. PermaNet<sup>® </sup>3.0 is impregnated with deltamethrin at 85 mg/m<sup>2 </sup>on the sides of the net and with deltamethrin and piperonyl butoxide on the roof. PermaNet<sup>® </sup>2.0 is impregnated with deltamethrin at 55 mg/m<sup>2 </sup>across the entire net.</p> <p>Methods</p> <p>The study was conducted in the station of Yaokoffikro, in central Côte d'Ivoire. The efficacy of intact unwashed and washed LLINs was compared over a 12-week period with a conventionally-treated net (CTN) washed to just before exhaustion. WHO cone bioassays were performed on sub-sections of the nets, using wild-resistant <it>An. gambiae </it>and Kisumu strains. Mosquitoes were collected five days per week and were identified to genus and species level and classified as dead or alive, then unfed or blood-fed.</p> <p>Results</p> <p>Mortality rates of over 80% from cone bioassays with wild-caught pyrethroid-resistant <it>An. gambiae </it>s.s were recorded only with unwashed PermaNet<sup>® </sup>3.0. Over 12 weeks, a total of 7,291 mosquitoes were collected. There were significantly more <it>An. gambiae </it>s.s. and <it>Culex </it>spp. caught in control huts than with other treatments (P < 0.001). The proportion of mosquitoes exiting the huts was significantly lower with the control than for the treatment arms (P < 0.001). Mortality rates with resistant <it>An. gambiae </it>s.s and <it>Culex </it>spp, were lower for the control than for other treatments (P < 0.001), which did not differ (P > 0.05) except for unwashed PermaNet<sup>® </sup>3.0 (P < 0.001), which gave significantly higher mortality (P < 0.001).</p> <p>Conclusions</p> <p>This study showed that unwashed PermaNet<sup>® </sup>3.0 caused significantly higher mortality against pyrethroid resistant <it>An. gambiae s.s </it>and <it>Culex </it>spp than PermaNet<sup>® </sup>2.0 and the CTN. The increased efficacy with unwashed PermaNet<sup>® </sup>3.0 over PermaNet<sup>® </sup>2.0 and the CTN was also demonstrated by higher KD and mortality rates (KD > 95% and mortality rate > 80%) in cone bioassays performed with wild pyrethroid-resistant <it>An. gambiae s.s </it>from Yaokoffikro.</p> |
url |
http://www.malariajournal.com/content/10/1/172 |
work_keys_str_mv |
AT koffialphonsinea efficacyofpermanetsupsup20andpermanetsupsup30againstinsecticideresistantitanophelesgambiaeitinexperimentalhutsincotedivoire AT koudoubenjaming efficacyofpermanetsupsup20andpermanetsupsup30againstinsecticideresistantitanophelesgambiaeitinexperimentalhutsincotedivoire AT malonedavid efficacyofpermanetsupsup20andpermanetsupsup30againstinsecticideresistantitanophelesgambiaeitinexperimentalhutsincotedivoire AT hemingwayjanet efficacyofpermanetsupsup20andpermanetsupsup30againstinsecticideresistantitanophelesgambiaeitinexperimentalhutsincotedivoire |
_version_ |
1725975252523024384 |