Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

The optimization of upstream and downstream processes for production of recombinant adeno-associated virus (rAAV) with consistent quality depends on the ability to rapidly characterize critical quality attributes (CQAs). In the context of rAAV production, the virus titer, capsid content, and aggrega...

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Bibliographic Details
Main Authors: Andreas L. Gimpel, Georgios Katsikis, Sha Sha, Andrew John Maloney, Moo Sun Hong, Tam N.T. Nguyen, Jacqueline Wolfrum, Stacy L. Springs, Anthony J. Sinskey, Scott R. Manalis, Paul W. Barone, Richard D. Braatz
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapies
viral vectors
adeno-associated virus
AAV
critical quality attributes
CQAs
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000255

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