Genetically Engineered-MSC Therapies for Non-unions, Delayed Unions and Critical-size Bone Defects

Genetically Engineered-MSC Therapies for Non-unions, Delayed Unions and Critical-size Bone Defects

The normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to...

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Bibliographic Details
Main Authors: Jaime Freitas, Susana Gomes Santos, Raquel Madeira Gonçalves, José Henrique Teixeira, Mário Adolfo Barbosa, Maria Inês Almeida
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
regeneration
osteogenic differentiation
immunomodulation
bone repair
Online Access:https://www.mdpi.com/1422-0067/20/14/3430

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