Common genetic variation in ETV6 is associated with colorectal cancer susceptibility
Genome-wide association studies have been performed to identify genetic variants that are associated with susceptibility to colorectal cancer. Here, the authors expand on these studies and identify a variant that regulates the expression of ETV6 and find that over-expression of ETV6 blocks cell prol...
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Nature Publishing Group
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11478 |
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doaj-564a923051f1417ea746e24f251160a42021-05-11T10:51:50ZengNature Publishing GroupNature Communications2041-17232016-05-01711910.1038/ncomms11478Common genetic variation in ETV6 is associated with colorectal cancer susceptibilityMeilin Wang0Dongying Gu1Mulong Du2Zhi Xu3Suzhan Zhang4Lingjun Zhu5Jiachun Lu6Rui Zhang7Jinliang Xing8Xiaoping Miao9Haiyan Chu10Zhibin Hu11Lei Yang12Cuiju Tang13Lei Pan14Haina Du15Jian Zhao16Jiangbo Du17Na Tong18Jielin Sun19Hongbing Shen20Jianfeng Xu21Zhengdong Zhang22Jinfei Chen23Department of Oncology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Oncology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical UniversityDepartment of Oncology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Oncology, First Affiliated Hospital of Nanjing Medical UniversityInstitute for Chemical Carcinogenesis, State Key Lab of Respiratory Disease, Guangzhou Medical UniversityDepartment of Colorectal Surgery, Liaoning Cancer Hospital and InstituteDepartment of Cell Biology and Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical UniversityJiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical UniversityInstitute for Chemical Carcinogenesis, State Key Lab of Respiratory Disease, Guangzhou Medical UniversityDepartment of Oncology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Oncology, First Affiliated Hospital of Nanjing Medical UniversityDepartment of Colorectal Surgery, Liaoning Cancer Hospital and InstituteDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical UniversityDepartment of Genetic Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical UniversityProgram for Personalized Cancer Care, NorthShore University Health SystemJiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical UniversityProgram for Personalized Cancer Care, NorthShore University Health SystemJiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical UniversityDepartment of Oncology, Nanjing First Hospital, Nanjing Medical UniversityGenome-wide association studies have been performed to identify genetic variants that are associated with susceptibility to colorectal cancer. Here, the authors expand on these studies and identify a variant that regulates the expression of ETV6 and find that over-expression of ETV6 blocks cell proliferation in vitro.https://doi.org/10.1038/ncomms11478 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Meilin Wang Dongying Gu Mulong Du Zhi Xu Suzhan Zhang Lingjun Zhu Jiachun Lu Rui Zhang Jinliang Xing Xiaoping Miao Haiyan Chu Zhibin Hu Lei Yang Cuiju Tang Lei Pan Haina Du Jian Zhao Jiangbo Du Na Tong Jielin Sun Hongbing Shen Jianfeng Xu Zhengdong Zhang Jinfei Chen |
| spellingShingle |
Meilin Wang Dongying Gu Mulong Du Zhi Xu Suzhan Zhang Lingjun Zhu Jiachun Lu Rui Zhang Jinliang Xing Xiaoping Miao Haiyan Chu Zhibin Hu Lei Yang Cuiju Tang Lei Pan Haina Du Jian Zhao Jiangbo Du Na Tong Jielin Sun Hongbing Shen Jianfeng Xu Zhengdong Zhang Jinfei Chen Common genetic variation in ETV6 is associated with colorectal cancer susceptibility Nature Communications |
| author_facet |
Meilin Wang Dongying Gu Mulong Du Zhi Xu Suzhan Zhang Lingjun Zhu Jiachun Lu Rui Zhang Jinliang Xing Xiaoping Miao Haiyan Chu Zhibin Hu Lei Yang Cuiju Tang Lei Pan Haina Du Jian Zhao Jiangbo Du Na Tong Jielin Sun Hongbing Shen Jianfeng Xu Zhengdong Zhang Jinfei Chen |
| author_sort |
Meilin Wang |
| title |
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility |
| title_short |
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility |
| title_full |
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility |
| title_fullStr |
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility |
| title_full_unstemmed |
Common genetic variation in ETV6 is associated with colorectal cancer susceptibility |
| title_sort |
common genetic variation in etv6 is associated with colorectal cancer susceptibility |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-05-01 |
| description |
Genome-wide association studies have been performed to identify genetic variants that are associated with susceptibility to colorectal cancer. Here, the authors expand on these studies and identify a variant that regulates the expression of ETV6 and find that over-expression of ETV6 blocks cell proliferation in vitro. |
| url |
https://doi.org/10.1038/ncomms11478 |
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