Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy
Purpose: The temporal lobe, a critical hub for cognition, also plays a central role in the regulation of autonomic cardiovascular functions. Lesions in this area are usually associated with abnormalities in the regulation of heart rate (HR) and blood pressure (BP). The analysis of the heart rate var...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00842/full |
id |
doaj-5653bba87ed84b3ba11606c8c2cfe8d6 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fedele Dono Giacomo Evangelista Valerio Frazzini Valerio Frazzini Catello Vollono Claudia Carrarini Mirella Russo Camilla Ferrante Vincenzo Di Stefano Vincenzo Di Stefano Luciano P. Marchionno Maria V. De Angelis Massimiliano Faustino Laura Bonanni Laura Bonanni Marco Onofrj Marco Onofrj Stefano L. Sensi Stefano L. Sensi Francesca Anzellotti |
spellingShingle |
Fedele Dono Giacomo Evangelista Valerio Frazzini Valerio Frazzini Catello Vollono Claudia Carrarini Mirella Russo Camilla Ferrante Vincenzo Di Stefano Vincenzo Di Stefano Luciano P. Marchionno Maria V. De Angelis Massimiliano Faustino Laura Bonanni Laura Bonanni Marco Onofrj Marco Onofrj Stefano L. Sensi Stefano L. Sensi Francesca Anzellotti Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy Frontiers in Neurology temporal lobe epilepsy interictal epileptic discharges heart rate variability autonomic nervous system cardiovascular risk |
author_facet |
Fedele Dono Giacomo Evangelista Valerio Frazzini Valerio Frazzini Catello Vollono Claudia Carrarini Mirella Russo Camilla Ferrante Vincenzo Di Stefano Vincenzo Di Stefano Luciano P. Marchionno Maria V. De Angelis Massimiliano Faustino Laura Bonanni Laura Bonanni Marco Onofrj Marco Onofrj Stefano L. Sensi Stefano L. Sensi Francesca Anzellotti |
author_sort |
Fedele Dono |
title |
Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy |
title_short |
Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy |
title_full |
Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy |
title_fullStr |
Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy |
title_full_unstemmed |
Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe Epilepsy |
title_sort |
interictal heart rate variability analysis reveals lateralization of cardiac autonomic control in temporal lobe epilepsy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-08-01 |
description |
Purpose: The temporal lobe, a critical hub for cognition, also plays a central role in the regulation of autonomic cardiovascular functions. Lesions in this area are usually associated with abnormalities in the regulation of heart rate (HR) and blood pressure (BP). The analysis of the heart rate variability (HRV) is useful to evaluate the cardiac parasympathetic nervous system activity. This study aims at comparing HRV changes occurring in two groups of patients suffering from Temporal Lobe Epilepsy (TLE). To that aim, we evaluated patients differentiated by the right or left location of the epileptic foci.Materials and Methods: Fifty-two adult patients with a diagnosis of TLE were enrolled. Each patient underwent a 20-min EEG + EKG recording in resting state. According to the localization of epileptic focus, patients were divided into two subgroups: right TLE (R-TLE) and left TLE (L-TLE). HRV parameters were calculated with a short-lasting analysis of EKG recordings. Time-domain and frequency domain-related, as well as non-linear analysis, parameters, were compared between the two groups.Results: Compared to the R-TLE group, L-TLE subjects showed a significant decrease in low frequency (LF) (p < 0.01) and low frequency/high-frequency ratio (LF/HF) (p < 0.001) as well as increased HF values (p < 0.01), a parameter indicative of the presence of an increased cardiac vagal tone. These results were also confirmed in the subgroup analysis that took into account the seizure types, responses to antiepileptic drugs, seizure frequencies, and etiology.Conclusions: The main finding of the study is that, compared to R-TLE, L-TLE is associated with increased cardiac vagal tone. These results indicate that patients with TLE exhibit a lateralized cardiac autonomic control. L-TLE patients may have a lower risk of developing cardiac dysfunctions and less susceptible to develop Sudden Death for Epilepsy (SUDEP). |
topic |
temporal lobe epilepsy interictal epileptic discharges heart rate variability autonomic nervous system cardiovascular risk |
url |
https://www.frontiersin.org/article/10.3389/fneur.2020.00842/full |
work_keys_str_mv |
AT fedeledono interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT giacomoevangelista interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT valeriofrazzini interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT valeriofrazzini interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT catellovollono interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT claudiacarrarini interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT mirellarusso interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT camillaferrante interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT vincenzodistefano interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT vincenzodistefano interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT lucianopmarchionno interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT mariavdeangelis interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT massimilianofaustino interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT laurabonanni interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT laurabonanni interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT marcoonofrj interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT marcoonofrj interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT stefanolsensi interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT stefanolsensi interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy AT francescaanzellotti interictalheartratevariabilityanalysisrevealslateralizationofcardiacautonomiccontrolintemporallobeepilepsy |
_version_ |
1724481204363722752 |
spelling |
doaj-5653bba87ed84b3ba11606c8c2cfe8d62020-11-25T03:52:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-08-011110.3389/fneur.2020.00842516940Interictal Heart Rate Variability Analysis Reveals Lateralization of Cardiac Autonomic Control in Temporal Lobe EpilepsyFedele Dono0Giacomo Evangelista1Valerio Frazzini2Valerio Frazzini3Catello Vollono4Claudia Carrarini5Mirella Russo6Camilla Ferrante7Vincenzo Di Stefano8Vincenzo Di Stefano9Luciano P. Marchionno10Maria V. De Angelis11Massimiliano Faustino12Laura Bonanni13Laura Bonanni14Marco Onofrj15Marco Onofrj16Stefano L. Sensi17Stefano L. Sensi18Francesca Anzellotti19Department of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyAP-HP, Epilepsy Unit, Pitié-Salpêtrière Hospital, and Sorbonne University, Paris, FranceBrain and Spine Institute (INSERM UMRS1127, CNRS UMR7225, Sorbonne Université), Pitié-Salpêtrière Hospital, Paris, FranceUnit of Neurophysiopathology and Sleep Medicine, Department of Geriatrics, Neurosciences and Orthopedics, IRCCS Policlinico Universitario Agostino Gemelli, Catholic University, Rome, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, Palermo, ItalyDepartment of Neurology, “SS Annunziata” Hospital, Chieti, ItalyDepartment of Neurology, “SS Annunziata” Hospital, Chieti, ItalyDepartment of Cardiology, “SS Annunziata” Hospital, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology - CAST, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology - CAST, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neuroscience, Imaging and Clinical Science, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyCenter for Advanced Studies and Technology - CAST, “G. D'Annunzio” University of Chieti-Pescara, Chieti, ItalyDepartment of Neurology, “SS Annunziata” Hospital, Chieti, ItalyPurpose: The temporal lobe, a critical hub for cognition, also plays a central role in the regulation of autonomic cardiovascular functions. Lesions in this area are usually associated with abnormalities in the regulation of heart rate (HR) and blood pressure (BP). The analysis of the heart rate variability (HRV) is useful to evaluate the cardiac parasympathetic nervous system activity. This study aims at comparing HRV changes occurring in two groups of patients suffering from Temporal Lobe Epilepsy (TLE). To that aim, we evaluated patients differentiated by the right or left location of the epileptic foci.Materials and Methods: Fifty-two adult patients with a diagnosis of TLE were enrolled. Each patient underwent a 20-min EEG + EKG recording in resting state. According to the localization of epileptic focus, patients were divided into two subgroups: right TLE (R-TLE) and left TLE (L-TLE). HRV parameters were calculated with a short-lasting analysis of EKG recordings. Time-domain and frequency domain-related, as well as non-linear analysis, parameters, were compared between the two groups.Results: Compared to the R-TLE group, L-TLE subjects showed a significant decrease in low frequency (LF) (p < 0.01) and low frequency/high-frequency ratio (LF/HF) (p < 0.001) as well as increased HF values (p < 0.01), a parameter indicative of the presence of an increased cardiac vagal tone. These results were also confirmed in the subgroup analysis that took into account the seizure types, responses to antiepileptic drugs, seizure frequencies, and etiology.Conclusions: The main finding of the study is that, compared to R-TLE, L-TLE is associated with increased cardiac vagal tone. These results indicate that patients with TLE exhibit a lateralized cardiac autonomic control. L-TLE patients may have a lower risk of developing cardiac dysfunctions and less susceptible to develop Sudden Death for Epilepsy (SUDEP).https://www.frontiersin.org/article/10.3389/fneur.2020.00842/fulltemporal lobe epilepsyinterictal epileptic dischargesheart rate variabilityautonomic nervous systemcardiovascular risk |