The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats
Abstract Background Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known...
Main Authors: | Saeedeh Asadi, Ali Roohbakhsh, Ali Shamsizadeh, Masoud Fereidoni, Elham Kordijaz, Ali Moghimi |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-08-01
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Series: | BMC Neuroscience |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12868-018-0445-9 |
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