Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism
Objective. To investigate the value of the PTX-3 test in evaluating the prognosis of acute pulmonary embolism (APE). Method. 117 APE patients were selected and divided into two groups according to plasma PTX-3 levels, including the group in which PTX−3≥3.0 ng/mL (n=42) and the group in which PTX−3&l...
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Hindawi Limited
2019-01-01
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Series: | Disease Markers |
Online Access: | http://dx.doi.org/10.1155/2019/2324515 |
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doaj-565ba142972a46858f11390c10352b232020-11-25T01:00:22ZengHindawi LimitedDisease Markers0278-02401875-86302019-01-01201910.1155/2019/23245152324515Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary EmbolismHaotian Yang0Jun Zhang1Ying Huan2Yawei Xu3Rong Guo4Department of Cardiology, Shanghai Tenth People’s Hospital, Shanghai 200072, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Shanghai 200072, ChinaTianjin Medical University, Tianjin 300060, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Shanghai 200072, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Shanghai 200072, ChinaObjective. To investigate the value of the PTX-3 test in evaluating the prognosis of acute pulmonary embolism (APE). Method. 117 APE patients were selected and divided into two groups according to plasma PTX-3 levels, including the group in which PTX−3≥3.0 ng/mL (n=42) and the group in which PTX−3<3.0 ng/mL (n=75). Patients were stratified into high-risk, medium-risk, and low-risk groups according to the Wells scores, and the PTX-3 levels were compared among the groups. Patients had been followed-up as well. Results. According to the Wells scores, 11 patients were classified as high-risk (9.4%) and 68 were medium-risk (58.1%), while 38 were low-risk (32.5%). The PTX-3 levels in different risk groups were statistically different (all P<0.05). During the follow-up period, 6 deaths occurred in the group with elevated PTX-3 (≥3.0 ng/mL), while 2 deaths occurred in the group with nonelevated PTX-3 (<3.0 ng/mL). The difference between the two groups was statistically significant (P<0.01). 13 patients were hospitalized due to recurrent pulmonary embolism, of which 12 were in the group with elevated PTX-3 (≥3.0 ng/mL), while 1 patient was in the group with nonelevated PTX-3 (<3.0 ng/mL). The difference was statistically significant (P<0.01). Conclusion. The plasma PTX-3 level in APE patients is correlated with PE risk stratification. There is a significant correlation between PTX-3 levels and PE-related cardiac deaths, as well as the prognosis of recurrent PE. PTX-3 can be used as a clinical indicator of PE prognosis.http://dx.doi.org/10.1155/2019/2324515 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haotian Yang Jun Zhang Ying Huan Yawei Xu Rong Guo |
spellingShingle |
Haotian Yang Jun Zhang Ying Huan Yawei Xu Rong Guo Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism Disease Markers |
author_facet |
Haotian Yang Jun Zhang Ying Huan Yawei Xu Rong Guo |
author_sort |
Haotian Yang |
title |
Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism |
title_short |
Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism |
title_full |
Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism |
title_fullStr |
Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism |
title_full_unstemmed |
Pentraxin-3 Levels Relate to the Wells Score and Prognosis in Patients with Acute Pulmonary Embolism |
title_sort |
pentraxin-3 levels relate to the wells score and prognosis in patients with acute pulmonary embolism |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2019-01-01 |
description |
Objective. To investigate the value of the PTX-3 test in evaluating the prognosis of acute pulmonary embolism (APE). Method. 117 APE patients were selected and divided into two groups according to plasma PTX-3 levels, including the group in which PTX−3≥3.0 ng/mL (n=42) and the group in which PTX−3<3.0 ng/mL (n=75). Patients were stratified into high-risk, medium-risk, and low-risk groups according to the Wells scores, and the PTX-3 levels were compared among the groups. Patients had been followed-up as well. Results. According to the Wells scores, 11 patients were classified as high-risk (9.4%) and 68 were medium-risk (58.1%), while 38 were low-risk (32.5%). The PTX-3 levels in different risk groups were statistically different (all P<0.05). During the follow-up period, 6 deaths occurred in the group with elevated PTX-3 (≥3.0 ng/mL), while 2 deaths occurred in the group with nonelevated PTX-3 (<3.0 ng/mL). The difference between the two groups was statistically significant (P<0.01). 13 patients were hospitalized due to recurrent pulmonary embolism, of which 12 were in the group with elevated PTX-3 (≥3.0 ng/mL), while 1 patient was in the group with nonelevated PTX-3 (<3.0 ng/mL). The difference was statistically significant (P<0.01). Conclusion. The plasma PTX-3 level in APE patients is correlated with PE risk stratification. There is a significant correlation between PTX-3 levels and PE-related cardiac deaths, as well as the prognosis of recurrent PE. PTX-3 can be used as a clinical indicator of PE prognosis. |
url |
http://dx.doi.org/10.1155/2019/2324515 |
work_keys_str_mv |
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