Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond s...

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Bibliographic Details
Main Authors: Adriana Arena, Carlo Bisignano, Giovanna Stassi, Angela Filocamo, Giuseppina Mandalari
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
HSV-2
cytokines
IL-17
almond skins
Online Access:http://www.mdpi.com/1420-3049/20/5/8816
Description
Summary:We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins.
ISSN:1420-3049

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