The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile

The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile

The electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes. Here, the authors present the crystal structure of Clostridium difficile EtfAB/Bcd and discuss the bifurcation mechanism for e...

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Main Authors: Julius K. Demmer, Nilanjan Pal Chowdhury, Thorsten Selmer, Ulrich Ermler, Wolfgang Buckel
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01746-3
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spelling doaj-5682c72d8b5c4535ae81aa69d64ef9a22021-05-11T07:16:03ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01746-3The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficileJulius K. Demmer0Nilanjan Pal Chowdhury1Thorsten Selmer2Ulrich Ermler3Wolfgang Buckel4Max-Planck-Institut für BiophysikLaboratorium für Mikrobiologie, Fachbereich Biologie and SYNMIKRO, Philipps-UniversitätFachbereich Chemie und Biotechnologie, FH AachenMax-Planck-Institut für BiophysikLaboratorium für Mikrobiologie, Fachbereich Biologie and SYNMIKRO, Philipps-UniversitätThe electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes. Here, the authors present the crystal structure of Clostridium difficile EtfAB/Bcd and discuss the bifurcation mechanism for electron flow.https://doi.org/10.1038/s41467-017-01746-3
collection DOAJ
language English
format Article
sources DOAJ
author Julius K. Demmer
Nilanjan Pal Chowdhury
Thorsten Selmer
Ulrich Ermler
Wolfgang Buckel
spellingShingle Julius K. Demmer
Nilanjan Pal Chowdhury
Thorsten Selmer
Ulrich Ermler
Wolfgang Buckel
The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
Nature Communications
author_facet Julius K. Demmer
Nilanjan Pal Chowdhury
Thorsten Selmer
Ulrich Ermler
Wolfgang Buckel
author_sort Julius K. Demmer
title The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
title_short The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
title_full The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
title_fullStr The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
title_full_unstemmed The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile
title_sort semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description The electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes. Here, the authors present the crystal structure of Clostridium difficile EtfAB/Bcd and discuss the bifurcation mechanism for electron flow.
url https://doi.org/10.1038/s41467-017-01746-3
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