Does aluminum exposure affect cognitive function? a comparative cross-sectional study.
<h4>Objectives</h4>This study assessed the cognitive function of aluminum-exposed participants from an alum mining zone, compared them with unexposed subjects, and aimed to elucidate the effect of aluminum exposure on cognition.<h4>Design</h4>This was a comparative cross-sect...
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doaj-5687bb6a8dfb4ab998a2f0fe9aa0e7652021-08-03T04:34:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024656010.1371/journal.pone.0246560Does aluminum exposure affect cognitive function? a comparative cross-sectional study.Tao ZhangFan HeShangtong LinXinyi WangFudong LiYujia ZhaiXue GuMengna WuJunfen Lin<h4>Objectives</h4>This study assessed the cognitive function of aluminum-exposed participants from an alum mining zone, compared them with unexposed subjects, and aimed to elucidate the effect of aluminum exposure on cognition.<h4>Design</h4>This was a comparative cross-sectional study. Univariate analyses were used to assess the differences between the aluminum-exposed and unexposed groups. Binary logistic regression models were applied to analyze the effect of aluminum exposure.<h4>Setting</h4>The aluminum-exposed participants were included from an alum mining zone and the unexposed subjects were residents from another district without alum-mine-related factories.<h4>Participants</h4>We included 539 aluminum-exposed participants (254 men, 285 women) and 1720 unexposed participants (692 men, 1028 women).<h4>Results</h4>The mean cognition score on Mini-Mental State Examination was 21.34 (± 6.81) for aluminum-exposed participants. The exposed group had 6.77 times (95% confidence interval, 5.09-9.00) more risk of cognitive impairment than the unexposed group, after adjusting for age, sex, and educational level. No statistically significant association was found between exposure duration and cognition.<h4>Conclusions</h4>This study demonstrated a significant association between aluminum exposure and lower cognitive function.https://doi.org/10.1371/journal.pone.0246560 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tao Zhang Fan He Shangtong Lin Xinyi Wang Fudong Li Yujia Zhai Xue Gu Mengna Wu Junfen Lin |
spellingShingle |
Tao Zhang Fan He Shangtong Lin Xinyi Wang Fudong Li Yujia Zhai Xue Gu Mengna Wu Junfen Lin Does aluminum exposure affect cognitive function? a comparative cross-sectional study. PLoS ONE |
author_facet |
Tao Zhang Fan He Shangtong Lin Xinyi Wang Fudong Li Yujia Zhai Xue Gu Mengna Wu Junfen Lin |
author_sort |
Tao Zhang |
title |
Does aluminum exposure affect cognitive function? a comparative cross-sectional study. |
title_short |
Does aluminum exposure affect cognitive function? a comparative cross-sectional study. |
title_full |
Does aluminum exposure affect cognitive function? a comparative cross-sectional study. |
title_fullStr |
Does aluminum exposure affect cognitive function? a comparative cross-sectional study. |
title_full_unstemmed |
Does aluminum exposure affect cognitive function? a comparative cross-sectional study. |
title_sort |
does aluminum exposure affect cognitive function? a comparative cross-sectional study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2021-01-01 |
description |
<h4>Objectives</h4>This study assessed the cognitive function of aluminum-exposed participants from an alum mining zone, compared them with unexposed subjects, and aimed to elucidate the effect of aluminum exposure on cognition.<h4>Design</h4>This was a comparative cross-sectional study. Univariate analyses were used to assess the differences between the aluminum-exposed and unexposed groups. Binary logistic regression models were applied to analyze the effect of aluminum exposure.<h4>Setting</h4>The aluminum-exposed participants were included from an alum mining zone and the unexposed subjects were residents from another district without alum-mine-related factories.<h4>Participants</h4>We included 539 aluminum-exposed participants (254 men, 285 women) and 1720 unexposed participants (692 men, 1028 women).<h4>Results</h4>The mean cognition score on Mini-Mental State Examination was 21.34 (± 6.81) for aluminum-exposed participants. The exposed group had 6.77 times (95% confidence interval, 5.09-9.00) more risk of cognitive impairment than the unexposed group, after adjusting for age, sex, and educational level. No statistically significant association was found between exposure duration and cognition.<h4>Conclusions</h4>This study demonstrated a significant association between aluminum exposure and lower cognitive function. |
url |
https://doi.org/10.1371/journal.pone.0246560 |
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