Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response

Fatal Leishmaniasis in the Absence of TNF Despite a Strong Th1 Response

Induction of inducible nitric oxide synthase (iNOS) in mononuclear phagocytes by IFN-γ and innate tumor necrosis factor (TNF) provide the basis for an effective immune response to the intracellular parasite Leishmania (L.) major. We previously observed a fatal visceral form of leishmaniasis in L. ma...

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Bibliographic Details
Main Authors: Phillip D Fromm, Jessica eKling, Annika eRemke, Christian eBogdan, Heinrich eKorner
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Microbiology
Subjects:
cutaneous leishmaniasis
Tumor necrosis factor
mouse models
IFN-γ
T cells subpopulations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01520/full

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