KIR3DL1-Negative CD8 T Cells and KIR3DL1-Negative Natural Killer Cells Contribute to the Advantageous Control of Early Human Immunodeficiency Virus Type 1 Infection in HLA-B Bw4 Homozygous Individuals

KIR3DL1-Negative CD8 T Cells and KIR3DL1-Negative Natural Killer Cells Contribute to the Advantageous Control of Early Human Immunodeficiency Virus Type 1 Infection in HLA-B Bw4 Homozygous Individuals

Bw4 homozygosity in human leukocyte antigen class B alleles has been associated with a delayed acquired immunodeficiency syndrome (AIDS) development and better control of human immunodeficiency virus type 1 (HIV-1) viral load (VL) than Bw6 homozygosity. Efficient CD8 T cell and natural killer (NK) c...

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Bibliographic Details
Main Authors: Xin Zhang, Xiaofan Lu, Christiane Moog, Lin Yuan, Zhiying Liu, Zhen Li, Wei Xia, Yuefang Zhou, Hao Wu, Tong Zhang, Bin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus type 1
immunity
KIR3DL1 receptor
acute/early infection
Bw4 homozygotes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01855/full

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