Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat
To investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD) for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were in...
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Sociedade Brasileira de Microbiologia
2015-06-01
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doaj-56b34ca0d11041c385827be1899474522020-11-24T23:23:58ZengSociedade Brasileira de MicrobiologiaBrazilian Journal of Microbiology1678-44052015-06-0146238939510.1590/S1517-838246220131278S1517-83822015000200389Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in ratYuanhong XieHongxing ZhangHui LiuLixia XiongXiuzhi GaoHui JiaZhengxing LianNengsheng TongTao HanTo investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD) for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were individually treated with three different dosages of K. marxianus M3+HCD or physiological saline+HCD via oral gavage for 28 d. The total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels in the serum and liver of the rats were measured using commercially available enzyme kits. In addition, the liver morphology was also examined using hematoxylin and eosin staining and optical microscopy. According to our results, the serum and liver TC, TG, LDL-C levels and atherogenic index (AI) were significantly decreased in rats orally administered K. marxianus M3 (p <0.01), and the HDL-C levels and anti atherogenic index (AAI) were significantly increased (p <0.01) compared to the control group. Moreover, K. marxianus M3 treatment also reduced the build-up of lipid droplets in the liver and exhibited normal hepatocytes, suggesting a protective effect of K. marxianus M3 in hyperlipidemic rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200389&lng=en&tlng=enKluyveromyces marxianushypercholesterolemiahigh-cholesterol diet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuanhong Xie Hongxing Zhang Hui Liu Lixia Xiong Xiuzhi Gao Hui Jia Zhengxing Lian Nengsheng Tong Tao Han |
spellingShingle |
Yuanhong Xie Hongxing Zhang Hui Liu Lixia Xiong Xiuzhi Gao Hui Jia Zhengxing Lian Nengsheng Tong Tao Han Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat Brazilian Journal of Microbiology Kluyveromyces marxianus hypercholesterolemia high-cholesterol diet |
author_facet |
Yuanhong Xie Hongxing Zhang Hui Liu Lixia Xiong Xiuzhi Gao Hui Jia Zhengxing Lian Nengsheng Tong Tao Han |
author_sort |
Yuanhong Xie |
title |
Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat |
title_short |
Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat |
title_full |
Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat |
title_fullStr |
Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat |
title_full_unstemmed |
Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat |
title_sort |
hypocholesterolemic effects of kluyveromyces marxianus m3 isolated from tibetan mushrooms on diet-induced hypercholesterolemia in rat |
publisher |
Sociedade Brasileira de Microbiologia |
series |
Brazilian Journal of Microbiology |
issn |
1678-4405 |
publishDate |
2015-06-01 |
description |
To investigate the effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rats, female Wistar rats were fed a high-cholesterol diet (HCD) for 28 d to generate hyperlipidemic models. Hyperlipidemic rats were assigned to four groups, which were individually treated with three different dosages of K. marxianus M3+HCD or physiological saline+HCD via oral gavage for 28 d. The total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels in the serum and liver of the rats were measured using commercially available enzyme kits. In addition, the liver morphology was also examined using hematoxylin and eosin staining and optical microscopy. According to our results, the serum and liver TC, TG, LDL-C levels and atherogenic index (AI) were significantly decreased in rats orally administered K. marxianus M3 (p <0.01), and the HDL-C levels and anti atherogenic index (AAI) were significantly increased (p <0.01) compared to the control group. Moreover, K. marxianus M3 treatment also reduced the build-up of lipid droplets in the liver and exhibited normal hepatocytes, suggesting a protective effect of K. marxianus M3 in hyperlipidemic rats. |
topic |
Kluyveromyces marxianus hypercholesterolemia high-cholesterol diet |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200389&lng=en&tlng=en |
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