Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor
Abstract Background SARS-CoV-2 causes COVID-19 which has a widely diverse disease profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify the SARS-CoV-2 pathogenic proteins that through host interactions cause the cellular damages underlying COVID-19 symptomatolog...
Main Authors: | Jin-Gu Lee, Weiliang Huang, Hangnoh Lee, Joyce van de Leemput, Maureen A. Kane, Zhe Han |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-03-01
|
Series: | Cell & Bioscience |
Online Access: | https://doi.org/10.1186/s13578-021-00568-7 |
Similar Items
-
Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment
by: Jun-yi Zhu, et al.
Published: (2021-03-01) -
Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2
by: Joyce van de Leemput, et al.
Published: (2021-06-01) -
SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence
by: Sameer Mohammad, et al.
Published: (2020-08-01) -
Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications
by: Antonio Valcarcel, et al.
Published: (2021-09-01) -
Characterization of SARS-CoV encoded accessory proteins ORF8a and ORF8
by: Yu-Yuan Huang, et al.
Published: (2009)