Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

Abstract Background Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation. TNFα–TNF receptor-1 (TNFR1) signaling contributes to the pathological...

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Bibliographic Details
Main Authors: Madhu Sudhana Saddala, Hu Huang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Translational Medicine
Subjects:
TNFα
TNFR1
Pharmacophore modeling
Zinc database
Docking
ADMET
Online Access:http://link.springer.com/article/10.1186/s12967-019-1965-5

Internet

http://link.springer.com/article/10.1186/s12967-019-1965-5

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