Current Advances in Sustained Release Microneedles
Microneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payl...
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Georg Thieme Verlag KG
2020-02-01
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Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1701435 |
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doaj-56b852c3043d40908b26cfea8c218c9d2021-03-17T08:40:46ZengGeorg Thieme Verlag KGPharmaceutical Fronts2628-50882628-50962020-02-010201e11e2210.1055/s-0040-1701435Current Advances in Sustained Release MicroneedlesGuangsheng Du0Xun Sun1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, PR ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, PR ChinaMicroneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payloads, limiting therapeutic utility of the biotherapeutics. Recently, several types of microneedles with sustained release properties, including slow-dissolving microneedles made of hydrophilic polymers, degradable microneedles made of hydrophobic polymers, and bioresponsive microneedles made of bioresponsive polymers, have been developed and investigated for intradermal delivery of the biotherapeutics, aiming for improving their therapeutic potency, reducing side effects and administration frequency, and further improving patient compliance. In this review, we introduced different types of microneedles that have been designed for sustained release of the payloads, summarized various applications of these microneedles, and discussed the future prospects of this technology.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1701435sustained releasepolymeric microneedlesdrug deliveryvaccines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guangsheng Du Xun Sun |
spellingShingle |
Guangsheng Du Xun Sun Current Advances in Sustained Release Microneedles Pharmaceutical Fronts sustained release polymeric microneedles drug delivery vaccines |
author_facet |
Guangsheng Du Xun Sun |
author_sort |
Guangsheng Du |
title |
Current Advances in Sustained Release Microneedles |
title_short |
Current Advances in Sustained Release Microneedles |
title_full |
Current Advances in Sustained Release Microneedles |
title_fullStr |
Current Advances in Sustained Release Microneedles |
title_full_unstemmed |
Current Advances in Sustained Release Microneedles |
title_sort |
current advances in sustained release microneedles |
publisher |
Georg Thieme Verlag KG |
series |
Pharmaceutical Fronts |
issn |
2628-5088 2628-5096 |
publishDate |
2020-02-01 |
description |
Microneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payloads, limiting therapeutic utility of the biotherapeutics. Recently, several types of microneedles with sustained release properties, including slow-dissolving microneedles made of hydrophilic polymers, degradable microneedles made of hydrophobic polymers, and bioresponsive microneedles made of bioresponsive polymers, have been developed and investigated for intradermal delivery of the biotherapeutics, aiming for improving their therapeutic potency, reducing side effects and administration frequency, and further improving patient compliance. In this review, we introduced different types of microneedles that have been designed for sustained release of the payloads, summarized various applications of these microneedles, and discussed the future prospects of this technology. |
topic |
sustained release polymeric microneedles drug delivery vaccines |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1701435 |
work_keys_str_mv |
AT guangshengdu currentadvancesinsustainedreleasemicroneedles AT xunsun currentadvancesinsustainedreleasemicroneedles |
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