Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators
CO<sub>2</sub> removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO<sub>2</sub> removal rate is necessary. It can either be determined by measuring...
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doaj-56c13f0a5eb046b0bbea89cbabe5e0d32021-03-03T00:05:51ZengMDPI AGBioengineering2306-53542021-03-018333310.3390/bioengineering8030033Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of OxygenatorsBenjamin Lukitsch0Paul Ecker1Martin Elenkov2Christoph Janeczek3Christian Jordan4Claus G. Krenn5Roman Ullrich6Margit Gfoehler7Michael Harasek8Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, 1060 Vienna, AustriaInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, 1060 Vienna, AustriaCCORE Technology GmbH, 1040 Vienna, AustriaCCORE Technology GmbH, 1040 Vienna, AustriaInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, 1060 Vienna, AustriaCCORE Technology GmbH, 1040 Vienna, AustriaCCORE Technology GmbH, 1040 Vienna, AustriaInstitute of Engineering Design and Product Development, TU Wien, 1060 Vienna, AustriaInstitute of Chemical, Environmental and Bioscience Engineering, TU Wien, 1060 Vienna, AustriaCO<sub>2</sub> removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO<sub>2</sub> removal rate is necessary. It can either be determined by measuring the CO<sub>2</sub> content in the exhaust gas of the oxygenator (sweep flow-based) or using blood gas analyzer data and a CO<sub>2</sub> solubility model (blood-based). In this study, we determined the CO<sub>2</sub> removal rate of a prototype oxygenator utilizing both methods in in vitro trials with bovine and in vivo trials with porcine blood. While the sweep flow-based method is reliably accurate, the blood-based method depends on the accuracy of the solubility model. In this work, we quantified performances of four different solubility models by calculating the deviation of the CO<sub>2</sub> removal rates determined by both methods. Obtained data suggest that the simplest model (Loeppky) performs better than the more complex ones (May, Siggaard-Anderson, and Zierenberg). The models of May, Siggaard-Anderson, and Zierenberg show a significantly better performance for in vitro bovine blood data than for in vivo porcine blood data. Furthermore, the suitability of the Loeppky model parameters for bovine blood (in vitro) and porcine blood (in vivo) is evaluated.https://www.mdpi.com/2306-5354/8/3/33blood oxygenatorcarbon dioxide (CO<sub>2</sub>) removalcarbon dioxide (CO<sub>2</sub>) solubility modelmodel performancemodel suitabilityevaluation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benjamin Lukitsch Paul Ecker Martin Elenkov Christoph Janeczek Christian Jordan Claus G. Krenn Roman Ullrich Margit Gfoehler Michael Harasek |
spellingShingle |
Benjamin Lukitsch Paul Ecker Martin Elenkov Christoph Janeczek Christian Jordan Claus G. Krenn Roman Ullrich Margit Gfoehler Michael Harasek Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators Bioengineering blood oxygenator carbon dioxide (CO<sub>2</sub>) removal carbon dioxide (CO<sub>2</sub>) solubility model model performance model suitability evaluation |
author_facet |
Benjamin Lukitsch Paul Ecker Martin Elenkov Christoph Janeczek Christian Jordan Claus G. Krenn Roman Ullrich Margit Gfoehler Michael Harasek |
author_sort |
Benjamin Lukitsch |
title |
Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators |
title_short |
Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators |
title_full |
Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators |
title_fullStr |
Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators |
title_full_unstemmed |
Suitable CO<sub>2</sub> Solubility Models for Determination of the CO<sub>2</sub> Removal Performance of Oxygenators |
title_sort |
suitable co<sub>2</sub> solubility models for determination of the co<sub>2</sub> removal performance of oxygenators |
publisher |
MDPI AG |
series |
Bioengineering |
issn |
2306-5354 |
publishDate |
2021-03-01 |
description |
CO<sub>2</sub> removal via membrane oxygenators during lung protective ventilation has become a reliable clinical technique. For further optimization of oxygenators, accurate prediction of the CO<sub>2</sub> removal rate is necessary. It can either be determined by measuring the CO<sub>2</sub> content in the exhaust gas of the oxygenator (sweep flow-based) or using blood gas analyzer data and a CO<sub>2</sub> solubility model (blood-based). In this study, we determined the CO<sub>2</sub> removal rate of a prototype oxygenator utilizing both methods in in vitro trials with bovine and in vivo trials with porcine blood. While the sweep flow-based method is reliably accurate, the blood-based method depends on the accuracy of the solubility model. In this work, we quantified performances of four different solubility models by calculating the deviation of the CO<sub>2</sub> removal rates determined by both methods. Obtained data suggest that the simplest model (Loeppky) performs better than the more complex ones (May, Siggaard-Anderson, and Zierenberg). The models of May, Siggaard-Anderson, and Zierenberg show a significantly better performance for in vitro bovine blood data than for in vivo porcine blood data. Furthermore, the suitability of the Loeppky model parameters for bovine blood (in vitro) and porcine blood (in vivo) is evaluated. |
topic |
blood oxygenator carbon dioxide (CO<sub>2</sub>) removal carbon dioxide (CO<sub>2</sub>) solubility model model performance model suitability evaluation |
url |
https://www.mdpi.com/2306-5354/8/3/33 |
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