Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy
Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high therapeutic efficiency and high security, a nanoassembly of Forster Resonance...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
KeAi Communications Co., Ltd.
2021-08-01
|
Series: | Bioactive Materials |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21000074 |
id |
doaj-56c2783934f64f67a1a89656827b94e3 |
---|---|
record_format |
Article |
spelling |
doaj-56c2783934f64f67a1a89656827b94e32021-05-08T04:23:34ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-08-016822912302Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapyXuanbo Zhang0Jianchen Xiong1Kaiyuan Wang2Han Yu3Bingjun Sun4Hao Ye5Zhiqiang Zhao6Ning Wang7Yuequan Wang8Shenwu Zhang9Wutong Zhao10Haotian Zhang11Zhonggui He12Cong Luo13Jin Sun14Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaSchool of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR ChinaDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR China; Corresponding author.Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, PR China; Corresponding author.Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high therapeutic efficiency and high security, a nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs is developed on basis of dual-mode photosensitizer co-loading and photocaging strategy. For proof-of-concept, an erythrocyte-camouflaged FRET pair co-assembly of chlorine e6 (Ce6, FRET donor) and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR, FRET acceptor) is investigated for breast cancer treatment. Notably, Ce6 in the nanoassemby is quenched by DiR and could be unlocked for photodynamic therapy (PDT) only when DiR is photobleached by 808-nm laser. As a result, Ce6-caused phototoxicity could be well controlled. Under cascaded laser irradiation (808–660 nm), tumor-localizing temperature rise following laser irradiation on DiR not only induces tumor cell apoptosis but also facilitates the tumor penetration of NPs, relieves tumor hypoxia, and promotes the PDT efficacy of Ce6. Such FRET pair-based nanoassembly provides a new strategy for developing multimodal phototherapy nanomedicines with high efficiency and good security.http://www.sciencedirect.com/science/article/pii/S2452199X21000074FRET pairCarrier-freeNanoassemblyErythrocyte membrane-camouflagedProgrammed synergistic phototherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xuanbo Zhang Jianchen Xiong Kaiyuan Wang Han Yu Bingjun Sun Hao Ye Zhiqiang Zhao Ning Wang Yuequan Wang Shenwu Zhang Wutong Zhao Haotian Zhang Zhonggui He Cong Luo Jin Sun |
spellingShingle |
Xuanbo Zhang Jianchen Xiong Kaiyuan Wang Han Yu Bingjun Sun Hao Ye Zhiqiang Zhao Ning Wang Yuequan Wang Shenwu Zhang Wutong Zhao Haotian Zhang Zhonggui He Cong Luo Jin Sun Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy Bioactive Materials FRET pair Carrier-free Nanoassembly Erythrocyte membrane-camouflaged Programmed synergistic phototherapy |
author_facet |
Xuanbo Zhang Jianchen Xiong Kaiyuan Wang Han Yu Bingjun Sun Hao Ye Zhiqiang Zhao Ning Wang Yuequan Wang Shenwu Zhang Wutong Zhao Haotian Zhang Zhonggui He Cong Luo Jin Sun |
author_sort |
Xuanbo Zhang |
title |
Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy |
title_short |
Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy |
title_full |
Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy |
title_fullStr |
Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy |
title_full_unstemmed |
Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy |
title_sort |
erythrocyte membrane-camouflaged carrier-free nanoassembly of fret photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2021-08-01 |
description |
Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high therapeutic efficiency and high security, a nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs is developed on basis of dual-mode photosensitizer co-loading and photocaging strategy. For proof-of-concept, an erythrocyte-camouflaged FRET pair co-assembly of chlorine e6 (Ce6, FRET donor) and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR, FRET acceptor) is investigated for breast cancer treatment. Notably, Ce6 in the nanoassemby is quenched by DiR and could be unlocked for photodynamic therapy (PDT) only when DiR is photobleached by 808-nm laser. As a result, Ce6-caused phototoxicity could be well controlled. Under cascaded laser irradiation (808–660 nm), tumor-localizing temperature rise following laser irradiation on DiR not only induces tumor cell apoptosis but also facilitates the tumor penetration of NPs, relieves tumor hypoxia, and promotes the PDT efficacy of Ce6. Such FRET pair-based nanoassembly provides a new strategy for developing multimodal phototherapy nanomedicines with high efficiency and good security. |
topic |
FRET pair Carrier-free Nanoassembly Erythrocyte membrane-camouflaged Programmed synergistic phototherapy |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X21000074 |
work_keys_str_mv |
AT xuanbozhang erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT jianchenxiong erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT kaiyuanwang erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT hanyu erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT bingjunsun erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT haoye erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT zhiqiangzhao erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT ningwang erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT yuequanwang erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT shenwuzhang erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT wutongzhao erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT haotianzhang erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT zhongguihe erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT congluo erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy AT jinsun erythrocytemembranecamouflagedcarrierfreenanoassemblyoffretphotosensitizerpairswithhightherapeuticefficiencyandhighsecurityforprogrammedcancersynergisticphototherapy |
_version_ |
1721455033823789056 |