Display technology on filamentous phage in the search for anti-infective biological agents
Introduction: The causes of antibiotic resistance are complex. The phage display technology has been used mainly to produce monoclonal antibodies (MAbs) and peptides directed against cancer or inflammatory disease targets. Today, this technology is recognized as a powerful tool for selecting novel p...
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Universidad Católica de Oriente
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doaj-56cc3aeb0958417cb799b9c57b08f1692020-11-25T01:51:03ZengUniversidad Católica de OrienteBionatura1390-93471390-93552016-01-01112330Display technology on filamentous phage in the search for anti-infective biological agentsNelson Santiago Vispo0Frank Camacho1Maritza Pupo Antúnez2Roberto Toledo3Oliberto Sánchez Ramos4Yachay Tech UniversityInstituto FinlayLaboratorio de Virología. Facultad de Biolog Universidad de la Habana CubaDepartamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción, ChileDepartamento de Farmacología, Faculta de Ciencias Biológicas, Universidad de Concepción, ChileIntroduction: The causes of antibiotic resistance are complex. The phage display technology has been used mainly to produce monoclonal antibodies (MAbs) and peptides directed against cancer or inflammatory disease targets. Today, this technology is recognized as a powerful tool for selecting novel peptides and antibodies that can bind to a wide range of antigens, ranging from whole cells to proteins and lipid targets. In this review, we highlight research that exploits the phage display technology to discover new drugs against infectious diseases, with a focus on antimicrobial peptides and antibodies. Methods: Basic and recent literature review was made, mainly focused on general aspects of phage display technology and the application in the search of new peptides or antibodies of pharmaceutical use to combat the infectious diseases transmitted by bacteria and virus. Results: Updated information on the selected topics is shown, with a guiding and practical approach aimed at researchers in the field of molecular biology to continue deepening the technology with special emphasis in the applications that have been developed in Cuba. Conclusions: Advances in methods of screening, manufacturing, and humanization technologies show that phage display technology can significantly contribute in the fight against clinically important pathogens. http://revistabionatura.com/phage-display.htmlBacteriophagescombinatorial librariesphage display technologybiopaninginfectious diseasespeptidesantibodies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nelson Santiago Vispo Frank Camacho Maritza Pupo Antúnez Roberto Toledo Oliberto Sánchez Ramos |
spellingShingle |
Nelson Santiago Vispo Frank Camacho Maritza Pupo Antúnez Roberto Toledo Oliberto Sánchez Ramos Display technology on filamentous phage in the search for anti-infective biological agents Bionatura Bacteriophages combinatorial libraries phage display technology biopaning infectious diseases peptides antibodies |
author_facet |
Nelson Santiago Vispo Frank Camacho Maritza Pupo Antúnez Roberto Toledo Oliberto Sánchez Ramos |
author_sort |
Nelson Santiago Vispo |
title |
Display technology on filamentous phage in the search for anti-infective biological agents |
title_short |
Display technology on filamentous phage in the search for anti-infective biological agents |
title_full |
Display technology on filamentous phage in the search for anti-infective biological agents |
title_fullStr |
Display technology on filamentous phage in the search for anti-infective biological agents |
title_full_unstemmed |
Display technology on filamentous phage in the search for anti-infective biological agents |
title_sort |
display technology on filamentous phage in the search for anti-infective biological agents |
publisher |
Universidad Católica de Oriente |
series |
Bionatura |
issn |
1390-9347 1390-9355 |
publishDate |
2016-01-01 |
description |
Introduction: The causes of antibiotic resistance are complex. The phage display technology has been used mainly to produce monoclonal antibodies (MAbs) and peptides directed against cancer or inflammatory disease targets. Today, this technology is recognized as a powerful tool for selecting novel peptides and antibodies that can bind to a wide range of antigens, ranging from whole cells to proteins and lipid targets. In this review, we highlight research that exploits the phage display technology to discover new drugs against infectious diseases, with a focus on antimicrobial peptides and antibodies.
Methods: Basic and recent literature review was made, mainly focused on general aspects of phage display technology and the application in the search of new peptides or antibodies of pharmaceutical use to combat the infectious diseases transmitted by bacteria and virus.
Results: Updated information on the selected topics is shown, with a guiding and practical approach aimed at researchers in the field of molecular biology to continue deepening the technology with special emphasis in the applications that have been developed in Cuba.
Conclusions: Advances in methods of screening, manufacturing, and humanization technologies show that phage display technology can significantly contribute in the fight against clinically important pathogens. |
topic |
Bacteriophages combinatorial libraries phage display technology biopaning infectious diseases peptides antibodies |
url |
http://revistabionatura.com/phage-display.html |
work_keys_str_mv |
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