Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach
Although atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances. We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in...
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Online Access: | http://dx.doi.org/10.1155/2014/429291 |
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doaj-56d3b05cc5eb4234aafac20afbe9b7ee2020-11-25T00:16:00ZengHindawi LimitedSchizophrenia Research and Treatment2090-20852090-20932014-01-01201410.1155/2014/429291429291Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance ApproachFlorent Auger0Patrick Duriez1Françoise Martin-Nizard2Nicolas Durieux3Régis Bordet4Olivier Pétrault5Université Lille Nord de France, 59000 Lille, FranceUniversité Lille Nord de France, 59000 Lille, FranceUniversité Lille Nord de France, 59000 Lille, FranceUniversité Lille Nord de France, 59000 Lille, FranceUniversité Lille Nord de France, 59000 Lille, FranceUniversité Lille Nord de France, 59000 Lille, FranceAlthough atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances. We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in order to develop a tool for predicting symptoms of the metabolic syndrome. Fat deposition and liver morphometry were assessed by T1-weighted imaging. Fatty acid composition and fat accumulations in tissues were determined using MR spectroscopy with and without water suppression, respectively. Risperidone treatment induced a weight gain accompanied with metabolic disturbances such as hyperglycemic status, an increase in visceral adipose tissue (VAT), and liver fat depositions. Correlations using Methylene-Water Ratio (MWR) and Polyunsaturated Index (PUI) demonstrated a concomitant increase in the weight gain, VAT and liver fat depositions, and a decrease in the quantity of polyunsaturated fatty acids. These results were consistent with a hepatic steatosis state. We evaluated the ability of MR techniques to detect subtle metabolic disorders induced by APDs. Thus, our model and methodology offer the possibility to investigate APDs side effects in order to improve the health conditions of schizophrenic patients.http://dx.doi.org/10.1155/2014/429291 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Florent Auger Patrick Duriez Françoise Martin-Nizard Nicolas Durieux Régis Bordet Olivier Pétrault |
spellingShingle |
Florent Auger Patrick Duriez Françoise Martin-Nizard Nicolas Durieux Régis Bordet Olivier Pétrault Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach Schizophrenia Research and Treatment |
author_facet |
Florent Auger Patrick Duriez Françoise Martin-Nizard Nicolas Durieux Régis Bordet Olivier Pétrault |
author_sort |
Florent Auger |
title |
Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach |
title_short |
Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach |
title_full |
Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach |
title_fullStr |
Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach |
title_full_unstemmed |
Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach |
title_sort |
long-term risperidone treatment induces visceral adiposity associated with hepatic steatosis in mice: a magnetic resonance approach |
publisher |
Hindawi Limited |
series |
Schizophrenia Research and Treatment |
issn |
2090-2085 2090-2093 |
publishDate |
2014-01-01 |
description |
Although atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances. We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in order to develop a tool for predicting symptoms of the metabolic syndrome. Fat deposition and liver morphometry were assessed by T1-weighted imaging. Fatty acid composition and fat accumulations in tissues were determined using MR spectroscopy with and without water suppression, respectively. Risperidone treatment induced a weight gain accompanied with metabolic disturbances such as hyperglycemic status, an increase in visceral adipose tissue (VAT), and liver fat depositions. Correlations using Methylene-Water Ratio (MWR) and Polyunsaturated Index (PUI) demonstrated a concomitant increase in the weight gain, VAT and liver fat depositions, and a decrease in the quantity of polyunsaturated fatty acids. These results were consistent with a hepatic steatosis state. We evaluated the ability of MR techniques to detect subtle metabolic disorders induced by APDs. Thus, our model and methodology offer the possibility to investigate APDs side effects in order to improve the health conditions of schizophrenic patients. |
url |
http://dx.doi.org/10.1155/2014/429291 |
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