Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat

Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat

Events of status epilepticus (SE) trigger the development of temporal lobe epilepsy (TLE), a type of focal epilepsy that is commonly drug-resistant and is highly comorbid with cognitive deficits. While SE-induced hippocampal injury, accompanied by gliosis and neuronal loss, typically disrupts cognit...

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Bibliographic Details
Main Authors: Season K. Wyatt-Johnson, Alexandra L. Sommer, Kevin Y. Shim, Amy L. Brewster
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neurology
Subjects:
microglia
pilocarpine
epileptogenesis
hippocampus
memory
astrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.651096/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.651096/full

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