PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease
Abstract Background The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). 15O-water positron emission tomography (PET) is considered the gold standard method for MBF quantificat...
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doaj-56dc6a84632141f48730bd0c33ecb2a22020-11-25T00:32:15ZengSpringerOpenEJNMMI Research2191-219X2017-06-01711710.1186/s13550-017-0296-xPET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery diseaseOsamu Manabe0Masanao Naya1Tadao Aikawa2Masahiko Obara3Keiichi Magota4Markus Kroenke5Noriko Oyama-Manabe6Kenji Hirata7Daiki Shinyama8Chietsugu Katoh9Nagara Tamaki10Department of Nuclear Medicine, Hokkaido University Graduate School of MedicineDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of MedicineDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of MedicineDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of MedicineDepartment of Nuclear Medicine, Hokkaido University Graduate School of MedicineDepartment of Nuclear Medicine, Hokkaido University Graduate School of MedicineDepartment of Diagnostic and Interventional Radiology, Hokkaido University HospitalDepartment of Nuclear Medicine, Hokkaido University Graduate School of MedicinePhilips Electronics JapanFaculty of Health Sciences, Hokkaido University Graduate School of MedicineDepartment of Nuclear Medicine, Hokkaido University Graduate School of MedicineAbstract Background The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). 15O-water positron emission tomography (PET) is considered the gold standard method for MBF quantification. However, MBF measurements in 15O-water PET with three-dimensional (3D) data acquisition, attenuation correction using computed tomography (CT), and time of flight have not been investigated in detail or validated. We conducted this study to evaluate the diagnostic potential of MBF measurements using PET/CT for a comparison of a control group and patients suspected of having CAD. Results Twenty-four patients with known or suspected CAD and eight age-matched healthy volunteers underwent rest and pharmacological stress perfusion studies with 15O-water PET/CT. The whole and three regional (left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) territory) MBF values were estimated. The CFR was computed as the ratio of the MBF during adenosine triphosphate-induced stress to the MBF at rest. The inter-observer variability was assessed by two independent observers. PET/CT using a 15O-water dose of 500 MBq and 3D data acquisition showed good image quality. A strong inter-observer correlation was detected in both the whole MBF analysis and the regional analysis with high intra-class correlation coefficients (r > 0.90, p < 0.001). Regional MBF at rest (LAD, 0.82 ± 0.15 ml/min/g; LCX, 0.83 ± 0.17 ml/min/g; RCA, 0.71 ± 0.20 ml/min/g; p = 0.74), MBF at stress (LAD, 3.77 ± 1.00 ml/min/g; LCX, 3.56 ± 1.01 ml/min/g; RCA, 3.27 ± 1.04 ml/min/g; p = 0.62), and CFR (LAD, 4.64 ± 0.90; LCX, 4.30 ± 0.64; RCA, 4.64 ± 0.96; p = 0.66) of the healthy volunteers showed no significant difference among the three regions. The global CFR of the patients was significantly lower than that of the volunteers (2.75 ± 0.81 vs. 4.54 ± 0.66, p = 0.0002). The regional analysis of the patients demonstrated that the CFR tended to be lower in the stenotic region compared to the non-stenotic region (2.43 ± 0.81 vs. 2.95 ± 0.92, p = 0.052). Conclusions 15O-water PET/CT with 3D data acquisition can be reliably used for the quantification of functional MBF and CFR in CAD patients.http://link.springer.com/article/10.1186/s13550-017-0296-xMyocardial blood flowCoronary flow reservePositron emission tomography15O-waterThree-dimensional data acquisition |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Osamu Manabe Masanao Naya Tadao Aikawa Masahiko Obara Keiichi Magota Markus Kroenke Noriko Oyama-Manabe Kenji Hirata Daiki Shinyama Chietsugu Katoh Nagara Tamaki |
spellingShingle |
Osamu Manabe Masanao Naya Tadao Aikawa Masahiko Obara Keiichi Magota Markus Kroenke Noriko Oyama-Manabe Kenji Hirata Daiki Shinyama Chietsugu Katoh Nagara Tamaki PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease EJNMMI Research Myocardial blood flow Coronary flow reserve Positron emission tomography 15O-water Three-dimensional data acquisition |
author_facet |
Osamu Manabe Masanao Naya Tadao Aikawa Masahiko Obara Keiichi Magota Markus Kroenke Noriko Oyama-Manabe Kenji Hirata Daiki Shinyama Chietsugu Katoh Nagara Tamaki |
author_sort |
Osamu Manabe |
title |
PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease |
title_short |
PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease |
title_full |
PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease |
title_fullStr |
PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease |
title_full_unstemmed |
PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease |
title_sort |
pet/ct scanning with 3d acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2017-06-01 |
description |
Abstract Background The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). 15O-water positron emission tomography (PET) is considered the gold standard method for MBF quantification. However, MBF measurements in 15O-water PET with three-dimensional (3D) data acquisition, attenuation correction using computed tomography (CT), and time of flight have not been investigated in detail or validated. We conducted this study to evaluate the diagnostic potential of MBF measurements using PET/CT for a comparison of a control group and patients suspected of having CAD. Results Twenty-four patients with known or suspected CAD and eight age-matched healthy volunteers underwent rest and pharmacological stress perfusion studies with 15O-water PET/CT. The whole and three regional (left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) territory) MBF values were estimated. The CFR was computed as the ratio of the MBF during adenosine triphosphate-induced stress to the MBF at rest. The inter-observer variability was assessed by two independent observers. PET/CT using a 15O-water dose of 500 MBq and 3D data acquisition showed good image quality. A strong inter-observer correlation was detected in both the whole MBF analysis and the regional analysis with high intra-class correlation coefficients (r > 0.90, p < 0.001). Regional MBF at rest (LAD, 0.82 ± 0.15 ml/min/g; LCX, 0.83 ± 0.17 ml/min/g; RCA, 0.71 ± 0.20 ml/min/g; p = 0.74), MBF at stress (LAD, 3.77 ± 1.00 ml/min/g; LCX, 3.56 ± 1.01 ml/min/g; RCA, 3.27 ± 1.04 ml/min/g; p = 0.62), and CFR (LAD, 4.64 ± 0.90; LCX, 4.30 ± 0.64; RCA, 4.64 ± 0.96; p = 0.66) of the healthy volunteers showed no significant difference among the three regions. The global CFR of the patients was significantly lower than that of the volunteers (2.75 ± 0.81 vs. 4.54 ± 0.66, p = 0.0002). The regional analysis of the patients demonstrated that the CFR tended to be lower in the stenotic region compared to the non-stenotic region (2.43 ± 0.81 vs. 2.95 ± 0.92, p = 0.052). Conclusions 15O-water PET/CT with 3D data acquisition can be reliably used for the quantification of functional MBF and CFR in CAD patients. |
topic |
Myocardial blood flow Coronary flow reserve Positron emission tomography 15O-water Three-dimensional data acquisition |
url |
http://link.springer.com/article/10.1186/s13550-017-0296-x |
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