Congenital haemangiomas: a single-centre retrospective review
Objective Congenital haemangiomas (CHs) are rare, benign vascular tumours that are fully developed at birth. Three subtypes of CHs have been described based on clinical behaviour: rapidly involuting CHs (RICHs), non-involuting CHs (NICHs) and partially involuting CHs (PICHs). We explore in our study...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2020-04-01
|
Series: | BMJ Paediatrics Open |
Online Access: | https://bmjpaedsopen.bmj.com/content/4/1/e000816.full |
id |
doaj-56e263432240453faa2ce113a84cdd6d |
---|---|
record_format |
Article |
spelling |
doaj-56e263432240453faa2ce113a84cdd6d2021-05-24T11:01:08ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722020-04-014110.1136/bmjpo-2020-000816Congenital haemangiomas: a single-centre retrospective reviewNicolas Grenier0Victoire Braun1Sorilla Prey2Carlotta Gurioli3Franck Boralevi4Alain Taieb5Maya Loot6Marie-Laure Jullie7Christine Léauté-Labrèze84 Department of Radiology, CHU de Bordeaux, Bordeaux, Aquitaine, France1 Dermatology, CHU de Bordeaux, Bordeaux, France1 Dermatology, CHU de Bordeaux, Bordeaux, France 3 Department of Specialized, Experimental and Diagnostic Medicine, Dermatology, University of Bologna, University of Bologna, Bologna, Emilia-Romagna, Italy1 Dermatology, CHU de Bordeaux, Bordeaux, France 1 Dermatology, CHU de Bordeaux, Bordeaux, France 5 Paediatric Surgery Department, CHU de Bordeaux, Bordeaux, Aquitaine, France6 Pathology Department, CHU de Bordeaux, PESSAC, Aquitaine, France1 Dermatology, CHU de Bordeaux, Bordeaux, France Objective Congenital haemangiomas (CHs) are rare, benign vascular tumours that are fully developed at birth. Three subtypes of CHs have been described based on clinical behaviour: rapidly involuting CHs (RICHs), non-involuting CHs (NICHs) and partially involuting CHs (PICHs). We explore in our study clinical, evolutionary and paraclinical characteristics of the three CH subtypes.Design Children with CH attending our department of paediatric dermatology at Bordeaux University Hospital over a 13-year period were retrospectively included. Epidemiological, clinical and evolutionary data, photographs and imaging results were reviewed. All available tissue samples were histologically examined.Results We included 57 patients: 22 with RICH, 22 with NICH and 13 with PICH. Males predominated (ratio 1.7); the most common CH location was on the limbs. RICH, NICH and PICH exhibited overlapping characteristics; all were single telangiectatic lesions with pale peripheral halos. At birth, NICHs were flat but RICHs and PICHs bulky. The median age at complete RICH involution was 12 months. One-third of CHs that appeared RICH-like at birth underwent incomplete involution to become PICHs. Heart failure and thrombocytopenia were rare complications. PICHs were frequently ulcerated. Pain was common for NICH and PICH. The imaging and histological data of the three CH subtypes were rather similar.Conclusions We describe the characteristics and evolution of the three CH subtypes using a case series. Certain overlapping features were apparent, reinforcing the hypothesis that RICH, NICH and PICH lie on the same pathological spectrum.https://bmjpaedsopen.bmj.com/content/4/1/e000816.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicolas Grenier Victoire Braun Sorilla Prey Carlotta Gurioli Franck Boralevi Alain Taieb Maya Loot Marie-Laure Jullie Christine Léauté-Labrèze |
spellingShingle |
Nicolas Grenier Victoire Braun Sorilla Prey Carlotta Gurioli Franck Boralevi Alain Taieb Maya Loot Marie-Laure Jullie Christine Léauté-Labrèze Congenital haemangiomas: a single-centre retrospective review BMJ Paediatrics Open |
author_facet |
Nicolas Grenier Victoire Braun Sorilla Prey Carlotta Gurioli Franck Boralevi Alain Taieb Maya Loot Marie-Laure Jullie Christine Léauté-Labrèze |
author_sort |
Nicolas Grenier |
title |
Congenital haemangiomas: a single-centre retrospective review |
title_short |
Congenital haemangiomas: a single-centre retrospective review |
title_full |
Congenital haemangiomas: a single-centre retrospective review |
title_fullStr |
Congenital haemangiomas: a single-centre retrospective review |
title_full_unstemmed |
Congenital haemangiomas: a single-centre retrospective review |
title_sort |
congenital haemangiomas: a single-centre retrospective review |
publisher |
BMJ Publishing Group |
series |
BMJ Paediatrics Open |
issn |
2399-9772 |
publishDate |
2020-04-01 |
description |
Objective Congenital haemangiomas (CHs) are rare, benign vascular tumours that are fully developed at birth. Three subtypes of CHs have been described based on clinical behaviour: rapidly involuting CHs (RICHs), non-involuting CHs (NICHs) and partially involuting CHs (PICHs). We explore in our study clinical, evolutionary and paraclinical characteristics of the three CH subtypes.Design Children with CH attending our department of paediatric dermatology at Bordeaux University Hospital over a 13-year period were retrospectively included. Epidemiological, clinical and evolutionary data, photographs and imaging results were reviewed. All available tissue samples were histologically examined.Results We included 57 patients: 22 with RICH, 22 with NICH and 13 with PICH. Males predominated (ratio 1.7); the most common CH location was on the limbs. RICH, NICH and PICH exhibited overlapping characteristics; all were single telangiectatic lesions with pale peripheral halos. At birth, NICHs were flat but RICHs and PICHs bulky. The median age at complete RICH involution was 12 months. One-third of CHs that appeared RICH-like at birth underwent incomplete involution to become PICHs. Heart failure and thrombocytopenia were rare complications. PICHs were frequently ulcerated. Pain was common for NICH and PICH. The imaging and histological data of the three CH subtypes were rather similar.Conclusions We describe the characteristics and evolution of the three CH subtypes using a case series. Certain overlapping features were apparent, reinforcing the hypothesis that RICH, NICH and PICH lie on the same pathological spectrum. |
url |
https://bmjpaedsopen.bmj.com/content/4/1/e000816.full |
work_keys_str_mv |
AT nicolasgrenier congenitalhaemangiomasasinglecentreretrospectivereview AT victoirebraun congenitalhaemangiomasasinglecentreretrospectivereview AT sorillaprey congenitalhaemangiomasasinglecentreretrospectivereview AT carlottagurioli congenitalhaemangiomasasinglecentreretrospectivereview AT franckboralevi congenitalhaemangiomasasinglecentreretrospectivereview AT alaintaieb congenitalhaemangiomasasinglecentreretrospectivereview AT mayaloot congenitalhaemangiomasasinglecentreretrospectivereview AT marielaurejullie congenitalhaemangiomasasinglecentreretrospectivereview AT christineleautelabreze congenitalhaemangiomasasinglecentreretrospectivereview |
_version_ |
1721428664880463872 |