Intracellular Hydrolysis of Small-Molecule <i>O</i>-Linked <i>N</i>-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition

Intracellular Hydrolysis of Small-Molecule <i>O</i>-Linked <i>N</i>-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition

<i>O</i>-GlcNAcylation is an essential post-translational modification that occurs on nuclear and cytoplasmic proteins, regulating their function in response to cellular stress and altered nutrient availability. <i>O</i>-GlcNAc transferase (OGT) is the enzyme that catalyzes t...

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Bibliographic Details
Main Authors: Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Marko Anderluh
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
ester hydrolysis
inhibitor
<i>O</i>-GlcNAc transferase
OGT inhibitor
Online Access:https://www.mdpi.com/1420-3049/25/15/3381

Internet

https://www.mdpi.com/1420-3049/25/15/3381

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