Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes
Current experimental and clinical data was analyzed to evaluate the ultrastructural changes of platelets and their interaction with other cells in conditions of impaired hemostasis during the type 2 diabetes development and following complications. Special attention was paid to determine the correla...
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2011-01-01
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Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2011-05-02/11pnotdt.pdf |
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doaj-56ec84aa768742bbbe833d965b83c1982020-11-24T21:03:59ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical Academy Морфологія1997-96652011-01-0152518Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetesPertseva N.O.Turlyun T.S.Current experimental and clinical data was analyzed to evaluate the ultrastructural changes of platelets and their interaction with other cells in conditions of impaired hemostasis during the type 2 diabetes development and following complications. Special attention was paid to determine the correlations between the revealed morphological changes of platelets and the functional and clinical data. We show that ultrastructural studies to reveal the morphological signs of platelets abilities to activate, as well as studies of their structural and functional changes in the conditions of hyperglycemia, and the features of their interaction with the blood cells and endothelial cells are among the most important questions in the field. Addressing these issues will contribute to the understanding of the important mechanisms of pathogenesis, as well as to explain the cascade of clinically relevant lesions, which not only complicate the course of the disease, but also determine its outcome.http://www.morphology.dp.ua/_pub/MORPHO-2011-05-02/11pnotdt.pdftype 2 diabeteshemostatic disordersplatelete morphologyintercellular interactions |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Pertseva N.O. Turlyun T.S. |
spellingShingle |
Pertseva N.O. Turlyun T.S. Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes Морфологія type 2 diabetes hemostatic disorders platelete morphology intercellular interactions |
author_facet |
Pertseva N.O. Turlyun T.S. |
author_sort |
Pertseva N.O. |
title |
Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes |
title_short |
Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes |
title_full |
Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes |
title_fullStr |
Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes |
title_full_unstemmed |
Clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes |
title_sort |
clinical and morphological parallels in conditions of impaired platelet-vascular hemostasis in patients with type 2 diabetes |
publisher |
Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
series |
Морфологія |
issn |
1997-9665 |
publishDate |
2011-01-01 |
description |
Current experimental and clinical data was analyzed to evaluate the ultrastructural changes of platelets and their interaction with other cells in conditions of impaired hemostasis during the type 2 diabetes development and following complications. Special attention was paid to determine the correlations between the revealed morphological changes of platelets and the functional and clinical data. We show that ultrastructural studies to reveal the morphological signs of platelets abilities to activate, as well as studies of their structural and functional changes in the conditions of hyperglycemia, and the features of their interaction with the blood cells and endothelial cells are among the most important questions in the field. Addressing these issues will contribute to the understanding of the important mechanisms of pathogenesis, as well as to explain the cascade of clinically relevant lesions, which not only complicate the course of the disease, but also determine its outcome. |
topic |
type 2 diabetes hemostatic disorders platelete morphology intercellular interactions |
url |
http://www.morphology.dp.ua/_pub/MORPHO-2011-05-02/11pnotdt.pdf |
work_keys_str_mv |
AT pertsevano clinicalandmorphologicalparallelsinconditionsofimpairedplateletvascularhemostasisinpatientswithtype2diabetes AT turlyunts clinicalandmorphologicalparallelsinconditionsofimpairedplateletvascularhemostasisinpatientswithtype2diabetes |
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