Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles
The investigation of reactivity of β,γ-unsaturated carbonyl compounds is of great synthetic value, especially in asymmetric transformations. Here, the authors report a catalytic asymmetric tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in presence of chiral N,N′-dioxide...
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2020-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-17681-9 |
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doaj-56eef85e6c18451bb5c7eefe77199ce32021-08-08T11:39:20ZengNature Publishing GroupNature Communications2041-17232020-08-0111111010.1038/s41467-020-17681-9Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazolesTengfei Kang0Liuzhen Hou1Sai Ruan2Weidi Cao3Xiaohua Liu4Xiaoming Feng5Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan UniversityKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan UniversityThe investigation of reactivity of β,γ-unsaturated carbonyl compounds is of great synthetic value, especially in asymmetric transformations. Here, the authors report a catalytic asymmetric tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in presence of chiral N,N′-dioxide metal catalysts.https://doi.org/10.1038/s41467-020-17681-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tengfei Kang Liuzhen Hou Sai Ruan Weidi Cao Xiaohua Liu Xiaoming Feng |
spellingShingle |
Tengfei Kang Liuzhen Hou Sai Ruan Weidi Cao Xiaohua Liu Xiaoming Feng Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles Nature Communications |
author_facet |
Tengfei Kang Liuzhen Hou Sai Ruan Weidi Cao Xiaohua Liu Xiaoming Feng |
author_sort |
Tengfei Kang |
title |
Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles |
title_short |
Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles |
title_full |
Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles |
title_fullStr |
Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles |
title_full_unstemmed |
Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles |
title_sort |
lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-08-01 |
description |
The investigation of reactivity of β,γ-unsaturated carbonyl compounds is of great synthetic value, especially in asymmetric transformations. Here, the authors report a catalytic asymmetric tandem isomerization/α-Michael addition of β,γ-unsaturated 2-acyl imidazoles in presence of chiral N,N′-dioxide metal catalysts. |
url |
https://doi.org/10.1038/s41467-020-17681-9 |
work_keys_str_mv |
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1721215730231279616 |